Gregory R J Thatcher
Overview
Explore the profile of Gregory R J Thatcher including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
132
Citations
1846
Followers
0
Related Specialties
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
1.
Cabel C, Guzman B, Alizadeh E, Li S, Holberg C, Wichaidit C, et al.
bioRxiv
. 2024 Oct;
PMID: 39416139
The sudden rise of the SARS-CoV-2 virus and the delay in the development of effective therapeutics to mitigate it made evident a need for ways to screen for compounds that...
2.
Ardini M, Aboagye S, Petukhova V, Kastrati I, Ippoliti R, Thatcher G, et al.
J Med Chem
. 2024 Sep;
67(18):15947-15967.
PMID: 39250602
Pyridine nucleotide-disulfide oxidoreductases are underexplored as drug targets, and thioredoxin reductases (TrxRs) stand out as compelling pharmacological targets. Selective TrxR inhibition is challenging primarily due to the reliance on covalent...
3.
Velma G, Laham M, Lewandowski C, Valencia-Olvera A, Balu D, Moore A, et al.
J Med Chem
. 2024 Aug;
67(17):15061-15079.
PMID: 39191400
Therapeutics enhancing apolipoprotein (APOE) positive function are a priority, because is the major genetic risk factor for Alzheimer's disease (AD). The function of APOE, the key constituent of lipoprotein particles...
4.
Velma G, Shen Z, Holberg C, Fu J, Soleymani F, Cooper L, et al.
J Med Chem
. 2024 Aug;
67(16):13681-13702.
PMID: 39102360
The SARS-CoV-2 papain-like protease (PLpro), essential for viral processing and immune response disruption, is a promising target for treating acute infection of SARS-CoV-2. To date, there have been no reports...
5.
Balu D, Valencia-Olvera A, Deshpande A, Narayanam S, Konasani S, Pattisapu S, et al.
Front Endocrinol (Lausanne)
. 2024 May;
15:1374825.
PMID: 38742194
Increasing evidence suggests that female individuals have a higher Alzheimer's disease (AD) risk associated with post-menopausal loss of circulating estradiol (E). However, clinical data are conflicting on whether E lowers...
6.
Velma G, Krider I, Alves E, Courey J, Laham M, Thatcher G
J Med Chem
. 2024 Apr;
67(8):5999-6026.
PMID: 38580317
Nicotinamide phosphoribosyltransferase (NAMPT) catalyzes the rate-limiting step in NAD biosynthesis via salvage of NAM formed from catabolism of NAD by proteins with NADase activity (e.g., PARPs, SIRTs, CD38). Depletion of...
7.
Gordon-Blake J, Ratia K, Weidig V, Velma G, Ackerman-Berrier M, Penton C, et al.
ACS Med Chem Lett
. 2024 Feb;
15(2):205-214.
PMID: 38352833
Evidence supports boosting nicotinamide adenine dinucleotide (NAD) to counteract oxidative stress in aging and neurodegenerative disease. One approach is to enhance the activity of nicotinamide phosphoribosyltransferase (NAMPT). Novel NAMPT positive...
8.
Li Y, Shen Z, Ratia K, Zhao J, Huang F, Dubrovyskyii O, et al.
J Med Chem
. 2024 Jan;
67(4):2712-2731.
PMID: 38295759
The bromodomain and extra-terminal domain (BET) proteins are epigenetic readers, regulating transcription via two highly homologous tandem bromodomains, BD1 and BD2. Clinical development of nonselective pan-BD BET inhibitors has been...
9.
Shen Z, Ratia K, Krider I, Ackerman-Berrier M, Penton C, Musku S, et al.
J Med Chem
. 2023 Dec;
66(24):16704-16727.
PMID: 38096366
Depletion of nicotinamide adenine dinucleotide (NAD) is associated with aging and disease, spurring the study of dietary supplements to replenish NAD. The catabolism of NAD to nicotinamide (NAM) requires the...
10.
Petukhova V, Aboagye S, Ardini M, Lullo R, Fata F, Byrne M, et al.
Nat Commun
. 2023 Jun;
14(1):3737.
PMID: 37349300
Only praziquantel is available for treating schistosomiasis, a disease affecting more than 200 million people. Praziquantel-resistant worms have been selected for in the lab and low cure rates from mass...