Ganesan Senthil Kumar
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Explore the profile of Ganesan Senthil Kumar including associated specialties, affiliations and a list of published articles.
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30
Citations
443
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Recent Articles
1.
Computational insight into crucial interaction between Pcf11 and Ydh1 for pre-mRNA 3'-end processing
Kaur M, Arya H, Sharma A, Singh G, Kumar G, Barnwal R
J Biomol Struct Dyn
. 2024 Dec;
:1-15.
PMID: 39660558
Pre-mRNA processing in eukaryotes involves capping, splicing, cleavage, and polyadenylation. Various proteins regulating this key transcriptional event in humans share considerable homology with proteins. Among these proteins, Pcf11 is a...
2.
Kaur M, Agrawal P, Singh G, Kumar G, Barnwal R
J Biomol Struct Dyn
. 2024 Nov;
:1-16.
PMID: 39522172
The cleavage and polyadenylation step are indispensable for pre-mRNA processing in eukaryotes. Defective 3'- end maturation of precursor mRNA has catastrophic effects, leading to several diseases in humans. This processing...
3.
Agrawal P, Arya H, Kumar G
PLoS One
. 2024 Oct;
19(10):e0311548.
PMID: 39453957
Dengue viral infection is caused by the Dengue virus, which spreads to humans through the bite of infected mosquitos. Dengue affects over half of the global population, with an estimated...
4.
Kumar G
Methods Mol Biol
. 2023 Dec;
2743:211-222.
PMID: 38147218
The formation of a reversible disulfide bond between the catalytic cysteine and a spatially neighboring cysteine (backdoor) in protein tyrosine phosphatases (PTPs) serves as a critical regulatory mechanism for maintaining...
5.
Hunashal Y, Kumar G, Choy M, DAndrea E, Da Silva Santiago A, Schoenle M, et al.
Nat Commun
. 2023 Jul;
14(1):4268.
PMID: 37460557
Penicillin-binding proteins (PBPs) are essential for the formation of the bacterial cell wall. They are also the targets of β-lactam antibiotics. In Enterococcus faecium, high levels of resistance to β-lactams...
6.
Srivastava G, Bajaj R, Kumar G, Gaudreau-LaPierre A, Nicolas H, Chamousset D, et al.
Cell Rep
. 2022 Nov;
41(9):111726.
PMID: 36450254
The serine/threonine protein phosphatase 1 (PP1) dephosphorylates hundreds of substrates by associating with >200 regulatory proteins to form specific holoenzymes. The major PP1 targeting protein in the nucleolus is RRP1B...
7.
Zhang R, Kumar G, Hansen U, Zoccheddu M, Sacchetti C, Holmes Z, et al.
JCI Insight
. 2022 Apr;
7(8).
PMID: 35451370
Systemic sclerosis (SSc) is a fibrotic autoimmune disease characterized by pathogenic activation of fibroblasts enhanced by local oxidative stress. The tyrosine phosphatase PTP4A1 was identified as a critical promoter of...
8.
Kumar G, Page R, Peti W
Biomol NMR Assign
. 2021 Jun;
15(2):243-248.
PMID: 34101142
The sequence-specific backbone assignment of the mitogen-activated protein kinase (MAPK) binding domain of the dual-specificity phosphatase 1 (DUSP1) has been accomplished using a uniformly [C, N]-labeled protein. These assignments will...
9.
Kumar G, Page R, Peti W
Protein Sci
. 2021 Feb;
30(4):908-913.
PMID: 33554397
Mitogen-activated protein kinase (MAPK; p38, ERK, and JNK) cascades are evolutionarily conserved signaling pathways that regulate the cellular response to a variety of extracellular stimuli, such as growth factors and...
10.
Kirsch K, Zeke A, Toke O, Sok P, Sethi A, Sebo A, et al.
Nat Commun
. 2020 Nov;
11(1):5769.
PMID: 33188182
Transcription factor phosphorylation at specific sites often activates gene expression, but how environmental cues quantitatively control transcription is not well-understood. Activating protein 1 transcription factors are phosphorylated by mitogen-activated protein...