Gail Lewis Phillips
Overview
Explore the profile of Gail Lewis Phillips including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
14
Citations
827
Followers
0
Related Specialties
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
1.
Zacharias N, Podust V, Kajihara K, Leipold D, Rosario G, Thayer D, et al.
Chem Sci
. 2022 Apr;
13(11):3147-3160.
PMID: 35414872
The antibody-drug conjugate (ADC) is a well-validated modality for the cell-specific delivery of small molecules with impact expanding rapidly beyond their originally-intended purpose of treating cancer. However, antibody-mediated delivery (AMD)...
2.
Phillips G, Guo J, Kiefer J, Proctor W, Bumbaca Yadav D, Dybdal N, et al.
Breast Cancer Res Treat
. 2021 Oct;
191(2):303-317.
PMID: 34708303
Purpose: Assessment of non-clinical safety signals relies on understanding species selectivity of antibodies. This is particularly important with antibody-drug conjugates, where it is key to determine target-dependent versus target-independent toxicity....
3.
Dragovich P, Adhikari P, Blake R, Blaquiere N, Chen J, Cheng Y, et al.
Bioorg Med Chem Lett
. 2020 Jan;
30(4):126907.
PMID: 31902710
Chimeric molecules which effect intracellular degradation of target proteins via E3 ligase-mediated ubiquitination (e.g., PROTACs) are currently of high interest in medicinal chemistry. However, these entities are relatively large compounds...
4.
Wang S, Chen B, Dragovich P, Pillow T, Staben L, Guo J, et al.
Drug Metab Dispos
. 2019 Mar;
47(5):547-555.
PMID: 30858239
Duocarmycins [including cyclopropyl pyrroloindole (CPI) or cyclopropyl benzoindole (CBI)] are a class of DNA minor-groove alkylators and seco-CPI/CBIs are synthetic pro-forms that can spirocyclize to CPI/CBI. Bis-CPI/CBIs are potential drug...
5.
Pei Z, Chen C, Chen J, Dela Cruz-Chuh J, Delarosa R, Deng Y, et al.
Mol Pharm
. 2018 Jul;
15(9):3979-3996.
PMID: 30040421
A number of cytotoxic pyrrolobenzodiazepine (PBD) monomers containing various disulfide-based prodrugs were evaluated for their ability to undergo activation (disulfide cleavage) in vitro in the presence of either glutathione (GSH)...
6.
Dragovich P, Blake R, Chen C, Chen J, Chuh J, den Besten W, et al.
Chemistry
. 2018 Mar;
24(19):4830-4834.
PMID: 29493023
A novel strategy to attach indole-containing payloads to antibodies through a carbamate moiety and a self-immolating, disulfide-based linker is described. This new strategy was employed to connect a selective estrogen...
7.
Phillips G
Breast Cancer Res Treat
. 2017 Jul;
165(2):469-470.
PMID: 28667455
No abstract available.
8.
Shepard H, Phillips G, Thanos C, Feldmann M
Clin Med (Lond)
. 2017 Jun;
17(3):220-232.
PMID: 28572223
Monoclonal antibody therapeutics have been approved for over 30 targets and diseases, most commonly cancer. Antibodies have become the new backbone of the pharmaceutical industry, which previously relied on small...
9.
Verma V, Pillow T, DePalatis L, Li G, Phillips G, Polson A, et al.
Bioorg Med Chem Lett
. 2015 Jan;
25(4):864-8.
PMID: 25613677
The cryptophycins are a potent class of cytotoxic agents that were evaluated as antibody drug conjugate (ADC) payloads. Free cryptophycin analog 1 displayed cell activity an order of magnitude more...
10.
Junttila T, Li J, Johnston J, Hristopoulos M, Clark R, Ellerman D, et al.
Cancer Res
. 2014 Sep;
74(19):5561-71.
PMID: 25228655
Clinical results from the latest strategies for T-cell activation in cancer have fired interest in combination immunotherapies that can fully engage T-cell immunity. In this study, we describe a trastuzumab-based...