Gabriele Fenini
Overview
Explore the profile of Gabriele Fenini including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
19
Citations
555
Followers
0
Related Specialties
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
1.
Efficient Generation of CRISPR/Cas9-Mediated Knockout Human Primary Keratinocytes by Electroporation
Karakaya T, Slaufova M, Di Filippo M, Hennig P, Fenini G, Kundig T, et al.
Methods Mol Biol
. 2024 Feb;
2849:73-86.
PMID: 38407798
Due to their full differentiation capacity in vitro, the culture of human primary keratinocytes (HPKs) represents a physiological model for answering basic biological and dermatological research questions, including those related...
2.
Fenini G, Karakaya T, Hennig P, Di Filippo M, Slaufova M, Beer H
J Invest Dermatol
. 2022 May;
142(9):2313-2322.
PMID: 35550825
In 2007, it was shown that DNA sequence variants of the human NLRP1 gene are associated with autoimmune and autoinflammatory diseases affecting mainly the skin. However, at that time, the...
3.
Meier-Schiesser B, Mellett M, Ramirez-Fort M, Maul J, Klug A, Winkelbeiner N, et al.
Int J Mol Sci
. 2021 Dec;
22(23).
PMID: 34884681
Apremilast (Otezla) is an oral small molecule phosphodiesterase 4 (PDE4) inhibitor approved for the treatment of psoriasis, psoriatic arthritis, and oral ulcers associated with Behçet's disease. While PDE4 inhibition overall...
4.
Hennig P, Fenini G, Di Filippo M, Karakaya T, Beer H
Biomedicines
. 2021 Jul;
9(7).
PMID: 34206503
p62 is a highly conserved, multi-domain, and multi-functional adaptor protein critically involved in several important cellular processes. Via its pronounced domain architecture, p62 binds to numerous interaction partners, thereby influencing...
5.
Fenini G, Karakaya T, Hennig P, Di Filippo M, Beer H
Int J Mol Sci
. 2020 Jul;
21(13).
PMID: 32640751
Inflammasomes represent a group of protein complexes that contribute to host defense against pathogens and repair processes upon the induction of inflammation. However, aberrant and chronic inflammasome activation underlies the...
6.
Hennig P, Fenini G, Di Filippo M, Beer H
Biomolecules
. 2020 Feb;
10(2).
PMID: 32053878
The skin represents an indispensable barrier between the organism and the environment and is the first line of defense against exogenous insults. The transcription factor NRF2 is a central regulator...
7.
Grossi S, Fenini G, Kockmann T, Hennig P, Di Filippo M, Beer H
J Invest Dermatol
. 2019 Dec;
140(7):1335-1345.e10.
PMID: 31877317
Inflammasome activation induces caspase-1-dependent secretion of the proinflammatory cytokine IL-1β. In addition, caspase-1 activates the protein GSDMD in immune cells, causing pyroptosis, a lytic type of cell death. In contrast,...
8.
Satoh T, Mellett M, Meier-Schiesser B, Fenini G, Otsuka A, Beer H, et al.
J Clin Invest
. 2019 Dec;
130(3):1417-1430.
PMID: 31805013
Epidermal growth factor receptor (EGFR) and MEK inhibitors (EGFRi/MEKi) are beneficial for the treatment of solid cancers but are frequently associated with severe therapy-limiting acneiform skin toxicities. The underlying molecular...
9.
Grossi S, Fenini G, Hennig P, Di Filippo M, Beer H
Methods Mol Biol
. 2019 Sep;
2109:125-145.
PMID: 31502220
The culture of epidermal human primary keratinocytes (HPKs) represents a well-established model in biological and dermatological research. In addition, HPKs are used in three-dimensional organotypic cultures (OTCs), and gene therapeutic...
10.
Sand J, Fenini G, Grossi S, Hennig P, Di Filippo M, Levesque M, et al.
J Invest Dermatol
. 2019 Feb;
139(8):1788-1797.e6.
PMID: 30738816
The inflammasome protein NLRP1 is an important innate immune sensor in human keratinocytes, and, together with ASC and caspase-1, it mediates the activation and secretion of the proinflammatory cytokines IL-1β...