Gabriel Pascual
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Explore the profile of Gabriel Pascual including associated specialties, affiliations and a list of published articles.
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21
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2308
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Recent Articles
1.
Perry S, Keogh E, Morton M, Koudstaal W, Pascual G
J Vis Exp
. 2019 Sep;
(150).
PMID: 31498318
The human antibody repertoire represents a largely untapped source of potential therapeutic antibodies and useful biomarkers. While current computational methods, such as next generation sequencing (NGS), yield enormous sets of...
2.
Gilman M, Furmanova-Hollenstein P, Pascual G, van t Wout A, Langedijk J, McLellan J
Nat Commun
. 2019 May;
10(1):2105.
PMID: 31068578
The respiratory syncytial virus (RSV) F glycoprotein is a class I fusion protein that mediates viral entry and is a major target of neutralizing antibodies. Structures of prefusion forms of...
3.
Li X, Koudstaal W, Fletcher L, Costa M, van Winsen M, Siregar B, et al.
Acta Neuropathol
. 2019 Feb;
137(5):825-836.
PMID: 30805666
Deposition of α-synuclein into Lewy bodies and Lewy neurites is the hallmark of Parkinson's disease (PD). It is hypothesized that α-synuclein pathology spreads by a "prion-like" mechanism (i.e., by seeded...
4.
Zhang H, Zhu X, Pascual G, Wadia J, Keogh E, Hoozemans J, et al.
Structure
. 2018 Oct;
26(12):1626-1634.e4.
PMID: 30318466
Aggregation of the hyperphosphorylated protein tau into neurofibrillary tangles and neuropil threads is a hallmark of Alzheimer disease (AD). Identification and characterization of the epitopes recognized by anti-tau antibodies might...
5.
Arija V, Villalobos F, Pedret R, Vinuesa A, Jovani D, Pascual G, et al.
Health Qual Life Outcomes
. 2018 Sep;
16(1):184.
PMID: 30217193
Background: Physical activity (PA) promotes cardiovascular health and health related quality of life (HRQoL), although the effect of that on blood pressure (BP) control has rarely been studied in hypertensive...
6.
van Ameijde J, Crespo R, Janson R, Juraszek J, Siregar B, Verveen H, et al.
Acta Neuropathol Commun
. 2018 Jul;
6(1):59.
PMID: 30001207
Aggregation of tau protein and spreading of tau aggregates are pivotal pathological processes in a range of neurological disorders. Accumulating evidence suggests that immunotherapy targeting tau may be a viable...
7.
Apetri A, Crespo R, Juraszek J, Pascual G, Janson R, Zhu X, et al.
Acta Neuropathol Commun
. 2018 Jun;
6(1):43.
PMID: 29855358
Misfolding and aggregation of tau protein are closely associated with the onset and progression of Alzheimer's Disease (AD). By interrogating IgG memory B cells from asymptomatic donors with tau peptides,...
8.
Jones H, Ritschel T, Pascual G, Brakenhoff J, Keogh E, Furmanova-Hollenstein P, et al.
PLoS Pathog
. 2018 Mar;
14(3):e1006935.
PMID: 29509814
Respiratory syncytial virus (RSV) is a major cause of severe lower respiratory tract infections in infants and the elderly, and yet there remains no effective treatment or vaccine. The surface...
9.
Pascual G, Wadia J, Zhu X, Keogh E, Kukrer B, van Ameijde J, et al.
Acta Neuropathol
. 2017 Mar;
133(5):767-783.
PMID: 28341999
Several reports have described the presence of antibodies against Alzheimer's disease-associated hyperphosphorylated forms of tau in serum of healthy individuals. To characterize the specificities that can be found, we interrogated...
10.
Stender J, Pascual G, Liu W, Kaikkonen M, Do K, Spann N, et al.
Mol Cell
. 2012 Aug;
48(1):28-38.
PMID: 22921934
Regulation of genes that initiate and amplify inflammatory programs of gene expression is achieved by signal-dependent exchange of coregulator complexes that function to read, write, and erase specific histone modifications...