Adrian Apetri
Overview
Explore the profile of Adrian Apetri including associated specialties, affiliations and a list of published articles.
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Articles
11
Citations
481
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Recent Articles
1.
Marreiro A, Van Kolen K, Sousa C, Temmerman L, Vasconcelos B, Crespo-Rodriguez R, et al.
BMC Mol Cell Biol
. 2020 Nov;
21(1):81.
PMID: 33183222
Background: Although several studies demonstrate prion-like properties of Tau fibrils, the effect of size in the seeding capacity of these aggregates is not fully understood. The aim of this study...
2.
Puchades C, Kukrer B, Diefenbach O, Sneekes-Vriese E, Juraszek J, Koudstaal W, et al.
Sci Rep
. 2019 Mar;
9(1):4735.
PMID: 30894620
Epitope characterization is critical for elucidating the mechanism of action of drug candidates. However, traditional high-resolution epitope mapping techniques are not well suited for screening numerous drug candidates recognizing a...
3.
Li X, Koudstaal W, Fletcher L, Costa M, van Winsen M, Siregar B, et al.
Acta Neuropathol
. 2019 Feb;
137(5):825-836.
PMID: 30805666
Deposition of α-synuclein into Lewy bodies and Lewy neurites is the hallmark of Parkinson's disease (PD). It is hypothesized that α-synuclein pathology spreads by a "prion-like" mechanism (i.e., by seeded...
4.
Crespo R, Koudstaal W, Apetri A
J Vis Exp
. 2018 Dec;
(141).
PMID: 30531722
Aggregation of tau protein and formation of paired helical filaments is a hallmark of Alzheimer's disease and other tauopathies. Compared to other proteins associated with neurodegenerative diseases, the reported in...
5.
De Marco D, Taggenbrock R, Crespo R, Koudstaal W, Ramsburg E, Apetri A
J Vis Exp
. 2018 Nov;
(141).
PMID: 30474638
Alzheimer's disease (AD) is a progressive neurodegenerative condition in which aggregated tau and amyloid proteins accumulate in the brain causing neuronal dysfunction which eventually leads to cognitive decline. Hyperphosphorylated tau...
6.
Zhang H, Zhu X, Pascual G, Wadia J, Keogh E, Hoozemans J, et al.
Structure
. 2018 Oct;
26(12):1626-1634.e4.
PMID: 30318466
Aggregation of the hyperphosphorylated protein tau into neurofibrillary tangles and neuropil threads is a hallmark of Alzheimer disease (AD). Identification and characterization of the epitopes recognized by anti-tau antibodies might...
7.
van Ameijde J, Crespo R, Janson R, Juraszek J, Siregar B, Verveen H, et al.
Acta Neuropathol Commun
. 2018 Jul;
6(1):59.
PMID: 30001207
Aggregation of tau protein and spreading of tau aggregates are pivotal pathological processes in a range of neurological disorders. Accumulating evidence suggests that immunotherapy targeting tau may be a viable...
8.
Apetri A, Crespo R, Juraszek J, Pascual G, Janson R, Zhu X, et al.
Acta Neuropathol Commun
. 2018 Jun;
6(1):43.
PMID: 29855358
Misfolding and aggregation of tau protein are closely associated with the onset and progression of Alzheimer's Disease (AD). By interrogating IgG memory B cells from asymptomatic donors with tau peptides,...
9.
Pascual G, Wadia J, Zhu X, Keogh E, Kukrer B, van Ameijde J, et al.
Acta Neuropathol
. 2017 Mar;
133(5):767-783.
PMID: 28341999
Several reports have described the presence of antibodies against Alzheimer's disease-associated hyperphosphorylated forms of tau in serum of healthy individuals. To characterize the specificities that can be found, we interrogated...
10.
Impagliazzo A, Milder F, Kuipers H, Wagner M, Zhu X, Hoffman R, et al.
Science
. 2015 Aug;
349(6254):1301-6.
PMID: 26303961
The identification of human broadly neutralizing antibodies (bnAbs) targeting the hemagglutinin (HA) stem revitalized hopes of developing a universal influenza vaccine. Using a rational design and library approach, we engineered...