Gabriel J Starrett
Overview
Explore the profile of Gabriel J Starrett including associated specialties, affiliations and a list of published articles.
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Articles
46
Citations
2164
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Recent Articles
31.
Shi K, Carpenter M, Banerjee S, Shaban N, Kurahashi K, Salamango D, et al.
Nat Struct Mol Biol
. 2016 Dec;
24(2):131-139.
PMID: 27991903
APOBEC-catalyzed cytosine-to-uracil deamination of single-stranded DNA (ssDNA) has beneficial functions in immunity and detrimental effects in cancer. APOBEC enzymes have intrinsic dinucleotide specificities that impart hallmark mutation signatures. Although numerous...
32.
Law E, Sieuwerts A, LaPara K, Leonard B, Starrett G, Molan A, et al.
Sci Adv
. 2016 Oct;
2(10):e1601737.
PMID: 27730215
Breast tumors often display extreme genetic heterogeneity characterized by hundreds of gross chromosomal aberrations and tens of thousands of somatic mutations. Tumor evolution is thought to be ongoing and driven...
33.
Starrett G, Luengas E, McCann J, Ebrahimi D, Temiz N, Love R, et al.
Nat Commun
. 2016 Sep;
7:12918.
PMID: 27650891
Cytosine mutations within TCA/T motifs are common in cancer. A likely cause is the DNA cytosine deaminase APOBEC3B (A3B). However, A3B-null breast tumours still have this mutational bias. Here we...
34.
Lee Y, Starrett G, Lee S, Yang R, Henzler C, Jameson S, et al.
J Immunol
. 2016 Jul;
197(4):1460-70.
PMID: 27385777
Invariant NKT cells differentiate into three predominant effector lineages in the steady state. To understand these lineages, we sorted undifferentiated invariant NK T progenitor cells and each effector population and...
35.
Akre M, Starrett G, Quist J, Temiz N, Carpenter M, Tutt A, et al.
PLoS One
. 2016 May;
11(5):e0155391.
PMID: 27163364
Molecular, cellular, and clinical studies have combined to demonstrate a contribution from the DNA cytosine deaminase APOBEC3B (A3B) to the overall mutation load in breast, head/neck, lung, bladder, cervical, ovarian,...
36.
Verhalen B, Starrett G, Harris R, Jiang M
J Virol
. 2016 May;
90(14):6379-6386.
PMID: 27147740
Unlabelled: The APOBEC3 family of DNA cytosine deaminases has important roles in innate immunity and cancer. It is unclear how DNA tumor viruses regulate these enzymes and how these interactions,...
37.
Leonard B, Starrett G, Maurer M, Oberg A, Van Bockstal M, Van Dorpe J, et al.
Clin Cancer Res
. 2016 Mar;
22(18):4746-55.
PMID: 27016308
Purpose: APOBEC3 DNA cytosine deaminase family members normally defend against viruses and transposons. However, deregulated APOBEC3 activity causes mutations in cancer. Because of broad expression profiles and varying mixtures of...
38.
Leonard B, McCann J, Starrett G, Kosyakovsky L, Luengas E, Molan A, et al.
Cancer Res
. 2015 Oct;
75(21):4538-47.
PMID: 26420215
Overexpression of the antiviral DNA cytosine deaminase APOBEC3B has been linked to somatic mutagenesis in many cancers. Human papillomavirus infection accounts for APOBEC3B upregulation in cervical and head/neck cancers, but...
39.
Lee Y, Wang H, Starrett G, Phuong V, Jameson S, Hogquist K
Immunity
. 2015 Sep;
43(3):566-78.
PMID: 26362265
Three subsets of invariant natural killer T (iNKT) cells have been identified, NKT1, NKT2, and NKT17, which produce distinct cytokines when stimulated, but little is known about their localization. Here,...
40.
Swanton C, McGranahan N, Starrett G, Harris R
Cancer Discov
. 2015 Jun;
5(7):704-12.
PMID: 26091828
Unlabelled: Deep sequencing technologies are revealing the complexities of cancer evolution, casting light on mutational processes fueling tumor adaptation, immune escape, and treatment resistance. Understanding mechanisms driving cancer diversity is...