Gabriel E Hoffman
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Explore the profile of Gabriel E Hoffman including associated specialties, affiliations and a list of published articles.
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73
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2798
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Recent Articles
11.
He C, Li A, Arachchilage K, Gupta C, Huang X, Zhao X, et al.
medRxiv
. 2024 Nov;
PMID: 39574856
The complexity of Alzheimer's disease (AD) manifests in diverse clinical phenotypes, including cognitive impairment and neuropsychiatric symptoms (NPSs). However, the etiology of these phenotypes remains elusive. To address this, the...
12.
Bigdeli T, Chatzinakos C, Bendl J, Barr P, Venkatesh S, Gorman B, et al.
medRxiv
. 2024 Sep;
PMID: 39252912
Large-scale genome-wide association studies of schizophrenia have uncovered hundreds of associated loci but with extremely limited representation of African diaspora populations. We surveyed electronic health records of 200,000 individuals of...
13.
Alldred M, Pidikiti H, Ibrahim K, Lee S, Heguy A, Hoffman G, et al.
Acta Neuropathol
. 2024 Aug;
148(1):16.
PMID: 39105932
We elucidated the molecular fingerprint of vulnerable excitatory neurons within select cortical lamina of individuals with Down syndrome (DS) for mechanistic understanding and therapeutic potential that also informs Alzheimer's disease...
14.
Alldred M, Pidikiti H, Ibrahim K, Lee S, Heguy A, Hoffman G, et al.
J Alzheimers Dis
. 2024 Jul;
100(s1):S341-S362.
PMID: 39031371
Background: Individuals with Down syndrome (DS) have intellectual disability and develop Alzheimer's disease (AD) pathology during midlife, particularly in the hippocampal component of the medial temporal lobe memory circuit. However,...
15.
Ruzicka W, Mohammadi S, Fullard J, Davila-Velderrain J, Subburaju S, Tso D, et al.
Science
. 2024 May;
384(6698):eadg5136.
PMID: 38781388
The complexity and heterogeneity of schizophrenia have hindered mechanistic elucidation and the development of more effective therapies. Here, we performed single-cell dissection of schizophrenia-associated transcriptomic changes in the human prefrontal...
16.
Zeng B, Bendl J, Deng C, Lee D, Misir R, Reach S, et al.
Science
. 2024 May;
384(6698):eadh4265.
PMID: 38781378
Nucleotide variants in cell type-specific gene regulatory elements in the human brain are risk factors for human disease. We measured chromatin accessibility in 1932 aliquots of sorted neurons and non-neurons...
17.
Emani P, Liu J, Clarke D, Jensen M, Warrell J, Gupta C, et al.
Science
. 2024 May;
384(6698):eadi5199.
PMID: 38781369
Single-cell genomics is a powerful tool for studying heterogeneous tissues such as the brain. Yet little is understood about how genetic variants influence cell-level gene expression. Addressing this, we uniformly...
18.
Dai R, Chu T, Zhang M, Wang X, Jourdon A, Wu F, et al.
Sci Adv
. 2024 May;
10(21):eadh2588.
PMID: 38781336
Sample-wise deconvolution methods estimate cell-type proportions and gene expressions in bulk tissue samples, yet their performance and biological applications remain unexplored, particularly in human brain transcriptomic data. Here, nine deconvolution...
19.
Emani P, Liu J, Clarke D, Jensen M, Warrell J, Gupta C, et al.
bioRxiv
. 2024 Apr;
PMID: 38562822
Single-cell genomics is a powerful tool for studying heterogeneous tissues such as the brain. Yet, little is understood about how genetic variants influence cell-level gene expression. Addressing this, we uniformly...
20.
Dong P, Voloudakis G, Fullard J, Hoffman G, Roussos P
Mol Psychiatry
. 2023 Dec;
29(3):782-792.
PMID: 38145985
Enhancers play an essential role in the etiology of schizophrenia; however, the dysregulation of enhancer activity and its impact on the regulome in schizophrenia remains understudied. To address this gap...