Kristen J Brennand
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Explore the profile of Kristen J Brennand including associated specialties, affiliations and a list of published articles.
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Citations
5555
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Recent Articles
1.
Cai Y, Kanyo J, Wilson R, Bathla S, Cardozo P, Tong L, et al.
Nat Aging
. 2025 Mar;
PMID: 40065072
Dystrophic neurites (also termed axonal spheroids) are found around amyloid deposits in Alzheimer's disease (AD), where they impair axonal electrical conduction, disrupt neural circuits and correlate with AD severity. Despite...
2.
Comandante-Lou N, Lama T, Chen K, Zhang J, Hu B, Liu S, et al.
bioRxiv
. 2025 Mar;
PMID: 40060644
Alzheimer's disease (AD) is marked by the coordinated emergence of disease-associated cell states across multiple cell types. Here, we first performed a meta-analysis of single-nucleus transcriptomic (snRNAseq) data from 869...
3.
Implications of gene × environment interactions in post-traumatic stress disorder risk and treatment
Seah C, Sidamon-Eristoff A, Huckins L, Brennand K
J Clin Invest
. 2025 Mar;
135(5).
PMID: 40026250
Exposure to traumatic stress is common in the general population. Variation in the brain's molecular encoding of stress potentially contributes to the heterogeneous clinical outcomes in response to traumatic experiences....
4.
Diaz-Perez S, DeLong J, Rivier C, Lee C, Askenase M, Zhu B, et al.
bioRxiv
. 2024 Dec;
PMID: 39713290
Vascular dementia (VaD) refers to a variety of dementias driven by cerebrovascular disease and is the second leading cause of dementia globally. VaD may be caused by ischemic strokes, intracerebral...
5.
Signer R, Seah C, Young H, Retallick-Townsley K, De Pins A, Cote A, et al.
medRxiv
. 2024 Dec;
PMID: 39649609
Genome-wide association studies identify common genomic variants associated with disease across a population. Individual environmental effects are often not included, despite evidence that environment mediates genomic regulation of higher order...
6.
Seah C, Breen M, Rusielewicz T, Bader H, Xu C, Hunter C, et al.
Nat Neurosci
. 2024 Dec;
28(1):214.
PMID: 39633181
No abstract available.
7.
Hicks E, Seah C, Deans M, Lee S, Johnston K, Cote A, et al.
bioRxiv
. 2024 Nov;
PMID: 39484441
Psychological trauma has profound effects on brain function and precipitates psychiatric disorders in vulnerable individuals, however, the molecular mechanisms linking trauma with psychiatric risk remain incompletely understood. Using RNA-seq data...
8.
Retallick-Townsley K, Lee S, Cartwright S, Cohen S, Sen A, Jia M, et al.
bioRxiv
. 2024 Jul;
PMID: 39026810
The prenatal environment can alter neurodevelopmental and clinical trajectories, markedly increasing risk for psychiatric disorders in childhood and adolescence. To understand if and how fetal exposures to stress and inflammation...
9.
Aligning Stem Cell Models and Postmortem Studies to Query Striatal Neurodevelopment in Schizophrenia
Brennand K
Am J Psychiatry
. 2024 Jun;
181(6):465-467.
PMID: 38822585
No abstract available.
10.
Huang Y, Wang M, Ni H, Zhang J, Li A, Hu B, et al.
Nat Neurosci
. 2024 May;
27(8):1489-1504.
PMID: 38802590
Communication between glial cells has a profound impact on the pathophysiology of Alzheimer's disease (AD). We reveal here that reactive astrocytes control cell distancing in peri-plaque glial nets, which restricts...