G Paolo Dotto
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Explore the profile of G Paolo Dotto including associated specialties, affiliations and a list of published articles.
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72
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3873
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Recent Articles
1.
Dotto G, Buckinx A, Ozdemir B, Simon C
Nat Rev Cancer
. 2024 Nov;
25(2):93-108.
PMID: 39587300
The androgen receptor (AR) signalling pathway has been intensively studied in the context of prostate cancer, where androgen deprivation therapy is part of the standard of care for metastatic disease....
2.
Ghosh S, Isma J, Ostano P, Mazzeo L, Toniolo A, Das M, et al.
Nat Commun
. 2024 Sep;
15(1):7984.
PMID: 39266569
Alterations in nuclear structure and function are hallmarks of cancer cells. Little is known about these changes in Cancer-Associated Fibroblasts (CAFs), crucial components of the tumor microenvironment. Loss of the...
3.
Mazzeo L, Ghosh S, Di Cicco E, Isma J, Tavernari D, Samarkina A, et al.
Nat Commun
. 2024 Feb;
15(1):1038.
PMID: 38310103
There are significant commonalities among several pathologies involving fibroblasts, ranging from auto-immune diseases to fibrosis and cancer. Early steps in cancer development and progression are closely linked to fibroblast senescence...
4.
Ghosh S, Isma J, Mazzeo L, Toniolo A, Simon C, Dotto G
bioRxiv
. 2023 Jul;
PMID: 37425957
Alterations of nuclear structure and function, and associated impact on gene transcription, are a hallmark of cancer cells. Little is known of these alterations in Cancer-Associated Fibroblasts (CAFs), a key...
5.
Goruppi S, Clocchiatti A, Bottoni G, Di Cicco E, Ma M, Tassone B, et al.
Nat Commun
. 2023 Feb;
14(1):887.
PMID: 36797248
Epigenetic mechanisms oversee epidermal homeostasis and oncogenesis. The identification of kinases controlling these processes has direct therapeutic implications. We show that ULK3 is a nuclear kinase with elevated expression levels...
6.
Capolupo L, Khven I, Lederer A, Mazzeo L, Glousker G, Ho S, et al.
Science
. 2022 Apr;
376(6590):eabh1623.
PMID: 35420948
Human cells produce thousands of lipids that change during cell differentiation and can vary across individual cells of the same type. However, we are only starting to characterize the function...
7.
Dotto G, Missero C
EMBO Rep
. 2021 Feb;
22(3):e52152.
PMID: 33554445
"Flash forward genetics" refers to a genetic approach based on the functional interaction of a given factor with unknown partner(s) converging on shared targets across evolutionary boundaries. A study by...
8.
Ma M, Ghosh S, Tavernari D, Katarkar A, Clocchiatti A, Mazzeo L, et al.
J Exp Med
. 2020 Oct;
218(2).
PMID: 33112375
Melanoma susceptibility differs significantly in male versus female populations. Low levels of androgen receptor (AR) in melanocytes of the two sexes are accompanied by heterogeneous expression at various stages of...
9.
Katarkar A, Bottoni G, Clocchiatti A, Goruppi S, Bordignon P, Lazzaroni F, et al.
Nat Commun
. 2020 Oct;
11(1):5126.
PMID: 33046701
Cancer associated fibroblasts (CAFs) are a key component of the tumor microenvironment. Genomic alterations in these cells remain a point of contention. We report that CAFs from skin squamous cell...
10.
Dotto G
EMBO Rep
. 2020 Jan;
21(2):e49924.
PMID: 31930672
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