G Martin Benson
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Explore the profile of G Martin Benson including associated specialties, affiliations and a list of published articles.
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17
Citations
279
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Recent Articles
1.
Gardes C, Chaput E, Staempfli A, Blum D, Richter H, Benson G
J Lipid Res
. 2013 Feb;
54(5):1283-99.
PMID: 23431047
Modulating bile acid synthesis has long been considered a good strategy by which to improve cholesterol homeostasis in humans. The farnesoid X receptor (FXR), the key regulator of bile acid...
2.
Gardes C, Blum D, Bleicher K, Chaput E, Ebeling M, Hartman P, et al.
J Lipid Res
. 2011 Apr;
52(6):1188-1199.
PMID: 21464203
It is claimed that apoA-I expression is repressed in mice by cholic acid (CA) and its taurine conjugate, taurocholic acid (TCA) via farnesoid X receptor (FXR) activation. We measured apoA-I...
3.
Cheng K, Benson G, Grimsditch D, Reid D, Connor S, Griffin J
Physiol Genomics
. 2010 Mar;
41(3):224-31.
PMID: 20197419
Failure to express or expression of dysfunctional low-density lipoprotein receptors (LDLR) causes familial hypercholesterolemia in humans, a disease characterized by elevated blood cholesterol concentrations, xanthomas, and coronary heart disease, providing...
4.
Guo J, Bot I, de Nooijer R, Hoffman S, Stroup G, Biessen E, et al.
Cardiovasc Res
. 2008 Nov;
81(2):278-85.
PMID: 19015136
Aims: Cathepsin K (CatK), an established drug target for osteoporosis, has been reported to be upregulated in atherosclerotic lesions. Due to its proteolytic activity, CatK may influence the atherosclerotic lesion...
5.
Bhatia V, Yun S, Leung V, Grimsditch D, Benson G, Botto M, et al.
Am J Pathol
. 2007 Jan;
170(1):416-26.
PMID: 17200212
We explored the role of the classic complement pathway in atherogenesis by intercrossing C1q-deficient mice (C1qa-/-) with low-density lipoprotein receptor knockout mice (Ldlr-/-). Mice were fed a normal rodent diet...
6.
Murphy N, Grimsditch D, Vidgeon-Hart M, Groot P, Overend P, Benson G, et al.
Dis Markers
. 2006 Jan;
21(4):181-90.
PMID: 16403953
Dietary antioxidants are reported to suppress cellular expression of chemokines and adhesion molecules that recruit monocytes to the artery wall during atherosclerosis. In the present study we measured the effect...
7.
Macphee C, Benson G, Shi Y, Zalewski A
Expert Opin Investig Drugs
. 2005 Jul;
14(6):671-9.
PMID: 16004595
Although the clinical benefit of statins is well established, these agents reduce the risk of cardiovascular events by only 20 - 40%, and the residual risk for high-risk patients is...
8.
Guo J, Van Eck M, de Waard V, Maeda N, Benson G, Groot P, et al.
Biochim Biophys Acta
. 2005 Jun;
1740(3):453-9.
PMID: 15949714
Objective: To selectively determine the role of leukocyte CC-chemokine receptor 2 (CCR2) in atherogenesis. Methods And Results: Bone marrow progenitor cells harvested from CCR2(+/+) mice were transplanted into irradiated CCR2(-/-)...
9.
Characterisation of the lipoprotein structure in the St. Thomas' Mixed Hyperlipidaemic (SMHL) rabbit
de Roos B, Caslake M, Milliner K, Benson G, Suckling K, Packard C
Atherosclerosis
. 2005 Jun;
181(1):63-8.
PMID: 15939055
Familial combined hyperlipidaemia (FCHL) is a complex genetic disorder of unknown aetiology. Study of this human condition over many decades has been hampered by likely genetic heterogeneity. In order to...
10.
Hirschfield G, Gallimore J, Kahan M, Hutchinson W, Sabin C, Benson G, et al.
Proc Natl Acad Sci U S A
. 2005 May;
102(23):8309-14.
PMID: 15919817
The association between circulating concentrations of C-reactive protein (CRP) and future atherothrombotic events has provoked speculation about a possible pathogenetic role of CRP. However, we show here that transgenic expression...