G L Stiles
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Explore the profile of G L Stiles including associated specialties, affiliations and a list of published articles.
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115
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2470
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Recent Articles
11.
Jacobson K, Park K, Jiang J, Kim Y, Olah M, Stiles G, et al.
Neuropharmacology
. 1997 Nov;
36(9):1157-65.
PMID: 9364471
The effects of putative A3 adenosine receptor antagonists of three diverse chemical classes (the flavonoid MRS 1067, the 6-phenyl-1,4-dihydropyridines MRS 1097 and MRS 1191, and the triazoloquinazoline MRS 1220) were...
12.
Palmer T, Stiles G
Neuropharmacology
. 1997 Nov;
36(9):1141-7.
PMID: 9364469
Pharmacological and molecular cloning studies have revealed the presence of four adenosine receptor (AR) subtypes, termed A1, A2A, A2B and A3. Given that the A1 and A3ARs can both bind...
13.
Palmer T, Harris C, Coote J, Stiles G
Mol Pharmacol
. 1997 Oct;
52(4):632-40.
PMID: 9380026
The A3 adenosine receptor (A3AR) contributes to several cardiovascular effects of adenosine, including antihypertensive and cardioprotective effects. Although several studies have detailed the mechanisms underlying agonist-mediated desensitization of the rat...
14.
Palmer T, Stiles G
Biochemistry
. 1997 Jan;
36(4):832-8.
PMID: 9020781
In an attempt to delineate the structural requirements necessary for agonist-induced desensitization, we have stably expressed wild-type and mutant A2a adenosine receptors (A2aARs) in Chinese hamster ovary cells and examined...
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Van Rhee A, Jiang J, Melman N, Olah M, Stiles G, Jacobson K
J Med Chem
. 1996 Jul;
39(15):2980-9.
PMID: 8709132
1,4-Dihydropyridine and pyridine derivatives bound to three subtypes of adenosine receptors in the micromolar range. Affinity was determined in radioligand binding assays at rat brain A1 and A2A receptors using...
18.
Palmer T, Benovic J, Stiles G
J Biol Chem
. 1996 Jun;
271(25):15272-8.
PMID: 8663009
The differing effects of short-term agonist exposure on the two inhibitory adenosine receptor (AR) subtypes have been examined using Chinese hamster ovary cells stably expressing the hemagglutinin epitope-tagged human A1AR...
19.
Karton Y, Jiang J, Ji X, Melman N, Olah M, Stiles G, et al.
J Med Chem
. 1996 Jun;
39(12):2293-301.
PMID: 8691424
A broad screening of phytochemicals has demonstrated that certain flavone and flavonol derivatives have a relatively high affinity at A3 adenosine receptors, with Ki values of > or = 1...
20.
Palmer T, Benovic J, Stiles G
J Biol Chem
. 1995 Dec;
270(49):29607-13.
PMID: 7494005
A3 adenosine receptor (A3AR) activation contributes to both the cardioprotective and antihypertensive effects of adenosine. To date, no studies have examined the mechanisms by which this receptor undergoes rapid homologous...