G E Landreth
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Explore the profile of G E Landreth including associated specialties, affiliations and a list of published articles.
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54
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2099
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Recent Articles
1.
Mariani M, Malm T, Lamb R, Jay T, Neilson L, Casali B, et al.
Sci Rep
. 2017 Feb;
7:42270.
PMID: 28205585
Alzheimer's disease (AD) is characterized by extensive neuron loss that accompanies profound impairments in memory and cognition. We examined the neuronally directed effects of the retinoid X receptor agonist bexarotene...
2.
Gamboa J, Blankenship D, Niemi J, Landreth G, Karl M, Hilow E, et al.
Neuroscience
. 2010 Aug;
170(3):846-57.
PMID: 20691766
Stroke is a leading cause of death and disability but has limited therapeutic options. Thiazolidinediones (TZDs), agonists for the nuclear receptor, peroxisome proliferator-activated receptor (PPAR)γ, reduce infarct volume and improve...
3.
Engel S, Creson T, Hao Y, Shen Y, Maeng S, Nekrasova T, et al.
Mol Psychiatry
. 2008 Jan;
14(4):448-61.
PMID: 18227838
The extracellular signal-regulated kinase (ERK) pathway mediates neuronal plasticity in the CNS. The mood stabilizers lithium and valproate activate the ERK pathway in prefrontal cortex and hippocampus and potentiate ERK...
4.
Victor N, Wanderi E, Gamboa J, Zhao X, Aronowski J, Deininger K, et al.
Eur J Neurosci
. 2006 Sep;
24(6):1653-63.
PMID: 17004929
Stroke is a devastating disease with limited treatment options. Recently, we found that the peroxisome proliferator-activated receptor-gamma (PPARgamma) agonists troglitazone and pioglitazone reduce injury and inflammation in a rat model...
5.
Sundararajan S, Gamboa J, Victor N, Wanderi E, Lust W, Landreth G
Neuroscience
. 2004 Dec;
130(3):685-96.
PMID: 15590152
Newly developed insulin-sensitizing agents, which target the nuclear receptor peroxisome proliferator-activated receptor-gamma have recently been appreciated to exhibit potent anti-inflammatory actions. Since stroke is associated with an intense inflammatory response,...
6.
Landreth G, Heneka M
Neurobiol Aging
. 2002 Jan;
22(6):937-44.
PMID: 11755002
The role of inflammatory processes in the brains of Alzheimer's Disease (AD) patients has recently attracted considerable interest. Indeed, the only demonstrated effective therapy for AD patients is long-term treatment...
7.
Combs C, Bates P, Karlo J, Landreth G
Neurochem Int
. 2001 Oct;
39(5-6):449-57.
PMID: 11578780
Amyloid deposition within the brains of Alzheimer's Disease patients results in the activation of microglial cells and the induction of a local inflammatory response. The interaction of microglia or monocytes...
8.
Bamberger M, Landreth G
Microsc Res Tech
. 2001 Jul;
54(2):59-70.
PMID: 11455613
The etiology of Alzheimer's disease (AD) involves a significant inflammatory component as evidenced by the presence of elevated levels of a diverse range of proinflammatory molecules in the AD brain....
9.
Kao S, Jaiswal R, Kolch W, Landreth G
J Biol Chem
. 2001 Mar;
276(21):18169-77.
PMID: 11278445
In PC12 cells, epidermal growth factor (EGF) transiently stimulates the mitogen-activated protein (MAP) kinases, ERK1 and ERK2, and provokes cellular proliferation. In contrast, nerve growth factor (NGF) stimulation leads to...
10.
Heneka M, Landreth G, Feinstein D
Ann Neurol
. 2001 Feb;
49(2):276.
PMID: 11220752
No abstract available.