G da Silva Xavier
Overview
Explore the profile of G da Silva Xavier including associated specialties, affiliations and a list of published articles.
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Articles
11
Citations
450
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Recent Articles
1.
Locke J, da Silva Xavier G, Dawe H, Rutter G, Harries L
Diabetologia
. 2013 Oct;
57(1):122-8.
PMID: 24149837
Aims/hypothesis: Type 2 diabetes is characterised by progressive beta cell dysfunction, with changes in gene expression playing a crucial role in its development. MicroRNAs (miRNAs) are post-transcriptional regulators of gene...
2.
da Silva Xavier G, Mondragon A, Sun G, Chen L, McGinty J, French P, et al.
Diabetologia
. 2012 Jun;
55(10):2667-2676.
PMID: 22717537
Aims/hypothesis: Individuals carrying type 2 diabetes risk alleles in TCF7L2 display decreased beta cell levels of T cell factor 7 like-2 (TCF7L2) immunoreactivity, and impaired insulin secretion and beta cell...
3.
Locke J, da Silva Xavier G, Rutter G, Harries L
Diabetologia
. 2011 Sep;
54(12):3078-82.
PMID: 21913056
Aims/hypothesis: Intronic single nucleotide polymorphisms within the transcription factor 7-like 2 (TCF7L2) gene are associated with risk of type 2 diabetes. It is widely hypothesised that the predisposing variation is...
4.
da Silva Xavier G, Farhan H, Kim H, Caxaria S, Johnson P, Hughes S, et al.
Diabetologia
. 2010 Dec;
54(4):819-27.
PMID: 21181396
Aims/hypothesis: We assessed whether per-arnt-sim (PAS) domain-containing protein kinase (PASK) is involved in the regulation of glucagon secretion. Methods: mRNA levels were measured in islets by quantitative PCR and in...
5.
Sun G, Tarasov A, McGinty J, McDonald A, da Silva Xavier G, Gorman T, et al.
Diabetologia
. 2010 Mar;
53(5):924-36.
PMID: 20221584
Aims/hypothesis: AMP-activated protein kinase (AMPK) is an evolutionarily conserved enzyme and a target of glucose-lowering agents, including metformin. However, the precise role or roles of the enzyme in controlling insulin...
6.
An R, da Silva Xavier G, Hao H, Semplici F, Rutter J, Rutter G
Biochem Soc Trans
. 2006 Oct;
34(Pt 5):791-3.
PMID: 17052199
The transcription factor PDX-1 (pancreatic duodenal homeobox-1) is required for normal pancreatic development and for the function of insulin-producing islet beta-cells in mammals. We have shown previously that glucose regulates...
7.
Reimann F, Williams L, da Silva Xavier G, Rutter G, Gribble F
Diabetologia
. 2004 Sep;
47(9):1592-601.
PMID: 15365617
Aims/hypothesis: Glucagon-like peptide-1 (GLP-1) and peptide YY (PYY) are secreted from enteroendocrine L cells in response to nutrient ingestion. As glutamine is an important metabolic fuel for the gut, the...
8.
Leclerc I, Viollet B, da Silva Xavier G, Kahn A, Rutter G
Biochem Soc Trans
. 2002 May;
30(2):307-11.
PMID: 12023870
AMP-activated protein kinase (AMPK) is a regulator of cellular metabolism in response to changes in the energy status of the cells. AMPK was known to shut down energy-consuming pathways in...
9.
da Silva Xavier G, Varadi A, Ainscow E, Rutter G
J Biol Chem
. 2000 Sep;
275(46):36269-77.
PMID: 10967119
Increases in glucose concentration control the transcription of the preproinsulin (PPI) gene and several other genes in the pancreatic islet beta-cell. Although recent data have demonstrated that secreted insulin may...
10.
Rafiq I, da Silva Xavier G, Hooper S, Rutter G
J Biol Chem
. 2000 May;
275(21):15977-84.
PMID: 10821851
Exposure of islet beta-cells to elevated glucose concentrations (30 versus 3 mm) prompts enhanced preproinsulin (PPI) gene transcription and the trans-location to the nucleoplasm of pancreatic duodenum homeobox-1 (PDX-1; Rafiq,...