L W Harries
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Explore the profile of L W Harries including associated specialties, affiliations and a list of published articles.
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24
Citations
530
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Recent Articles
1.
Negligible senescence in naked mole rats may be a consequence of well-maintained splicing regulation
Lee B, Smith M, Buffenstein R, Harries L
Geroscience
. 2020 Jan;
42(2):633-651.
PMID: 31927681
Naked mole-rats (NMRs) have amongst the longest lifespans relative to body size of any known, non-volant mammalian species. They also display an enhanced stress resistance phenotype, negligible senescence and very...
2.
Jeffery N, Richardson S, Beall C, Harries L
Exp Cell Res
. 2017 Nov;
361(2):284-291.
PMID: 29107069
Interaction between islet cell subtypes and the extracellular matrix influences beta-cell function in mammals. The tissue architecture of rodent islets is very different to that of human islets; cell-to-cell communication...
3.
Pilling L, Joehanes R, Kacprowski T, Peters M, Jansen R, Karasik D, et al.
Physiol Genomics
. 2015 Oct;
48(1):1-11.
PMID: 26487704
Lower muscle strength in midlife predicts disability and mortality in later life. Blood-borne factors, including growth differentiation factor 11 (GDF11), have been linked to muscle regeneration in animal models. We...
4.
Locke J, da Silva Xavier G, Dawe H, Rutter G, Harries L
Diabetologia
. 2013 Oct;
57(1):122-8.
PMID: 24149837
Aims/hypothesis: Type 2 diabetes is characterised by progressive beta cell dysfunction, with changes in gene expression playing a crucial role in its development. MicroRNAs (miRNAs) are post-transcriptional regulators of gene...
5.
Morrison F, Locke J, Arif M, Murray A, Brown J, Harries L
Exp Clin Endocrinol Diabetes
. 2013 Jul;
121(7):413-9.
PMID: 23839539
Type 2 diabetes (T2D) is characterized by impaired beta cell function and insulin resistance. T2D susceptibility genes identified by Genome-wide association studies (GWAS) are likely to have roles in both...
6.
Pilling L, Harries L, Powell J, Llewellyn D, Ferrucci L, Melzer D
J Gerontol A Biol Sci Med Sci
. 2012 Mar;
67(5):511-9.
PMID: 22454374
Background: Successful aging depends in part on delaying age-related disease onsets until later in life. Conditions including coronary artery disease, Alzheimer's disease, prostate cancer, and type 2 diabetes are moderately...
7.
Locke J, da Silva Xavier G, Rutter G, Harries L
Diabetologia
. 2011 Sep;
54(12):3078-82.
PMID: 21913056
Aims/hypothesis: Intronic single nucleotide polymorphisms within the transcription factor 7-like 2 (TCF7L2) gene are associated with risk of type 2 diabetes. It is widely hypothesised that the predisposing variation is...
8.
Harries L
Diabet Med
. 2011 Jun;
28(9):1010-7.
PMID: 21699562
The past few years have seen huge advances in our understanding of the genetics of diabetes. However, definition of the mechanisms that underpin these observations is less clear. It is...
9.
Wirsing A, Johnstone K, Harries L, Ellard S, Ryffel G, Stanik J, et al.
Diabet Med
. 2010 Jun;
27(6):631-5.
PMID: 20546279
Aims: Mutations in HNF4A cause a form of monogenic beta-cell diabetes. We aimed to identify mutations in the pancreas-specific P2 promoter of HNF4A in families with suspected HNF4A diabetes and...
10.
Locke J, Ellard S, Norwood V, Harries L
Diabet Med
. 2009 Aug;
26(5):569-70.
PMID: 19646202
No abstract available.