G C Ness
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Explore the profile of G C Ness including associated specialties, affiliations and a list of published articles.
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83
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823
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Recent Articles
1.
McLean M, Zhao Z, Ness G
Endocrine
. 2010 Dec;
3(10):695-703.
PMID: 21153157
Hepatic low density lipoprotein receptor (LDLR), 3-hydroxy-3-methylglutaryl coenyzme A reductase (HMGR), cholesterol 7α-hydroxylase, and sterol carrier protein-2 are important proteins associated with the uptake, synthesis, degradation and transport of cellular...
2.
Ness G, Gertz K, Holland R
Arch Biochem Biophys
. 2001 Nov;
395(2):233-8.
PMID: 11697861
Binding of sterol response element binding protein 1a to sterol response element-1 (SRE-1) in the promoter region of lanosterol 14 alpha-demethylase (14DM) has been demonstrated previously. Decreased 14DM activity has...
3.
Fitzky B, Moebius F, Asaoka H, Waage-Baudet H, Xu L, Xu G, et al.
J Clin Invest
. 2001 Sep;
108(6):905-15.
PMID: 11560960
Smith-Lemli-Opitz/RSH syndrome (SLOS), a relatively common birth-defect mental-retardation syndrome, is caused by mutations in DHCR7, whose product catalyzes an obligate step in cholesterol biosynthesis, the conversion of 7-dehydrocholesterol to cholesterol....
4.
Ness G, Chambers C
Proc Soc Exp Biol Med
. 2000 Apr;
224(1):8-19.
PMID: 10782041
Regulation of the expression of hepatic 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase by the major end product of the biosynthetic pathway, cholesterol, and by various hormones is critical to maintaining constant...
5.
Ness G, Lopez D, Chambers C, Zhao Z, Beach D, KO S, et al.
Arch Biochem Biophys
. 1998 Sep;
357(2):259-64.
PMID: 9735166
The mechanisms by which oxylanosterols regulate expression of hepatic 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase and lower serum cholesterol levels were examined by using a novel nonmetabolizable oxylanosterol mimic, 15-oxa-32-vinyl-lanost-8-ene-3 beta,...
6.
Ness G, Lopez D, Chambers C, Newsome W, Cornelius P, Long C, et al.
Biochem Pharmacol
. 1998 Aug;
56(1):121-9.
PMID: 9698096
The mechanisms by which thyroid hormone (triiodothyronine (T3)) and a thyromimetic, 2-amino-3-(3,5-dibromo-4-[4-hydroxy-3-(6-oxo-1,6-dihydro-pyridazin -3-ylmethyl)-phenoxyl]-phenyl)propionic acid (L-94901), lower plasma low density lipoprotein (LDL) cholesterol and raise plasma high density lipoprotein (HDL) cholesterol...
7.
Chambers C, Ness G
Arch Biochem Biophys
. 1998 Jun;
354(2):317-22.
PMID: 9637742
The level of gene expression at which dietary cholesterol exerts feedback regulation on hepatic 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase was investigated using young male Sprague-Dawley rats. Previous studies suggested that...
8.
Lopez D, Chambers C, Keller R, Ness G
Arch Biochem Biophys
. 1998 Apr;
351(2):159-66.
PMID: 9514656
The mechanism by which depletion of hepatic cholesterol levels, achieved by inhibition of squalene synthase, alters hepatic LDL receptor, HMG-CoA reductase, and cholesterol 7alpha-hydroxylase gene expression was investigated by measuring...
9.
Ness G, Chambers C, Lopez D
J Lipid Res
. 1998 Feb;
39(1):75-84.
PMID: 9469588
The effects of atorvastatin on the expression of the hepatic HMG-CoA reductase and LDL receptor genes were investigated in rats. Like the other statins, atorvastatin increased the rate of degradation...
10.
Lopez D, Ness G
Arch Biochem Biophys
. 1997 Aug;
344(1):215-9.
PMID: 9244400
The mechanism by which dietary cholesterol regulates expression of the hepatic low-density lipoprotein (LDL) receptor was investigated. In a previous study (Arch. Biochem. Biophys. 325, 242-248, 1996), we demonstrated that...