Fumiko Tazoe
Overview
Explore the profile of Fumiko Tazoe including associated specialties, affiliations and a list of published articles.
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Articles
12
Citations
223
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Recent Articles
1.
Nagashima S, Yagyu H, Tozawa R, Tazoe F, Takahashi M, Kitamine T, et al.
J Lipid Res
. 2015 Mar;
56(5):998-1005.
PMID: 25755092
Squalene synthase (SS) catalyzes the biosynthesis of squalene, the first specific intermediate in the cholesterol biosynthetic pathway. To test the feasibility of lowering plasma cholesterol by inhibiting hepatic SS, we...
2.
Takahashi M, Yagyu H, Tazoe F, Nagashima S, Ohshiro T, Okada K, et al.
J Lipid Res
. 2013 Feb;
54(4):1124-34.
PMID: 23378601
The role of macrophage lipoprotein lipase (LpL) in the development of atherosclerosis and adiposity was examined in macrophage LpL knockout (MLpLKO) mice. MLpLKO mice were generated using cre-loxP gene targeting....
3.
Nagashima S, Yagyu H, Ohashi K, Tazoe F, Takahashi M, Ohshiro T, et al.
Arterioscler Thromb Vasc Biol
. 2012 Jun;
32(8):1824-31.
PMID: 22701022
Objective: 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGCR) catalyzes the rate-limiting step in cholesterol biosynthesis and has proven to be an effective target of lipid-lowering drugs, statins. The aim of this study...
4.
Wang X, Osuga J, Tazoe F, Okada K, Nagashima S, Takahashi M, et al.
J Atheroscler Thromb
. 2011 May;
18(8):713-9.
PMID: 21597230
Lecithin-cholesterol acyltransferase (LCAT) is an important enzyme involved in the esterification of cholesterol. Here, we report a novel point mutation in the LCAT gene of a 63-year-old female with characteristics...
5.
Nagashima S, Yagyu H, Takahashi N, Kurashina T, Takahashi M, Tsuchita T, et al.
J Atheroscler Thromb
. 2010 Nov;
18(3):190-9.
PMID: 21081832
Aim: Adipocyte lipolysis is mediated by a family of triglyceride (TG) lipases consisting of hormone-sensitive lipase (LIPE), adipose triglyceride lipase (PNPLA2) and carboxylesterase 1 (CES1); however, little is known about...
6.
Eto K, Tumenbayar B, Nagashima S, Tazoe F, Miyamoto M, Takahashi M, et al.
Diabetes Res Clin Pract
. 2010 May;
89(1):52-7.
PMID: 20452080
Fibroblast growth factor 21 (FGF21) has been identified as a novel metabolic regulator. This cross-sectional study was performed to clarify how serum FGF21 levels were associated with clinical parameters in...
7.
Nakayama K, Bayasgalan T, Tazoe F, Yanagisawa Y, Gotoh T, Yamanaka K, et al.
Hum Genet
. 2010 Apr;
127(6):685-90.
PMID: 20364269
Recent genome-wide association studies (GWASs) showed that single nucleotide polymorphisms (SNPs) in FADS1/FADS2 were associated with plasma lipid concentrations in populations with European ancestry. We investigated the associations between the...
8.
Sekiya M, Osuga J, Nagashima S, Ohshiro T, Igarashi M, Okazaki H, et al.
Cell Metab
. 2009 Sep;
10(3):219-28.
PMID: 19723498
Cholesterol ester (CE)-laden macrophage foam cells are the hallmark of atherosclerosis, and the hydrolysis of intracellular CE is one of the key steps in foam cell formation. Although hormone-sensitive lipase...
9.
Tazoe F, Yagyu H, Okazaki H, Igarashi M, Eto K, Nagashima S, et al.
Biochem Biophys Res Commun
. 2008 Sep;
376(1):111-5.
PMID: 18762171
Initial step toward the reverse-cholesterol transport is cholesterol efflux that is mediated by the ATP-binding cassette transporter A1 (ABCA1). However, it is unknown how the cholesteryl ester (CE) hydrolysis induces...
10.
Inaba T, Yagyu H, Itabashi N, Tazoe F, Fujita N, Nagashima S, et al.
Hypertens Res
. 2008 Aug;
31(5):999-1005.
PMID: 18712055
Fibrates, peroxisome proliferator-activated receptor a agonists, are widely used as lipid-lowering agents with anti-atherogenic activity. However, conflicting results have been reported with regard to their pharmacological effects on plasma lipoprotein...