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Frederic Baudat

Explore the profile of Frederic Baudat including associated specialties, affiliations and a list of published articles. Areas
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Articles 32
Citations 1864
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Recent Articles
11.
Cole F, Baudat F, Grey C, Keeney S, de Massy B, Jasin M
Nat Genet . 2014 Aug; 46(10):1072-80. PMID: 25151354
The ability to examine all chromatids from a single meiosis in yeast tetrads has been indispensable for defining the mechanisms of homologous recombination initiated by DNA double-strand breaks (DSBs). Using...
12.
Baudat F, Imai Y, de Massy B
Nat Rev Genet . 2013 Oct; 14(11):794-806. PMID: 24136506
During meiosis, a programmed induction of DNA double-strand breaks (DSBs) leads to the exchange of genetic material between homologous chromosomes. These exchanges increase genome diversity and are essential for proper...
13.
Wu H, Mathioudakis N, Diagouraga B, Dong A, Dombrovski L, Baudat F, et al.
Cell Rep . 2013 Oct; 5(1):13-20. PMID: 24095733
PRDM9, a histone lysine methyltransferase, is a key determinant of the localization of meiotic recombination hot spots in humans and mice and the only vertebrate protein known to be involved...
14.
Ishmukhametova A, Chen J, Bernard R, de Massy B, Baudat F, Boyer A, et al.
Hum Mutat . 2013 May; 34(8):1080-4. PMID: 23649991
Pathogenic complex genomic rearrangements are being increasingly characterized at the nucleotide level, providing unprecedented opportunities to evaluate the complexities of mutational mechanisms. Here, we report the molecular characterization of a...
15.
Kauppi L, Barchi M, Lange J, Baudat F, Jasin M, Keeney S
Genes Dev . 2013 Apr; 27(8):873-86. PMID: 23599345
Different organisms display widely different numbers of the programmed double-strand breaks (DSBs) that initiate meiotic recombination (e.g., hundreds per meiocyte in mice and humans vs. dozens in nematodes), but little...
16.
Reynolds A, Qiao H, Yang Y, Chen J, Jackson N, Biswas K, et al.
Nat Genet . 2013 Feb; 45(3):269-78. PMID: 23396135
Crossing-over ensures accurate chromosome segregation during meiosis, and every pair of chromosomes obtains at least one crossover, even though the majority of recombination sites yield non-crossovers. A putative regulator of...
17.
Flachs P, Mihola O, Simecek P, Gregorova S, Schimenti J, Matsui Y, et al.
PLoS Genet . 2012 Nov; 8(11):e1003044. PMID: 23133405
The Dobzhansky-Muller model of incompatibilities explains reproductive isolation between species by incorrect epistatic interactions. Although the mechanisms of speciation are of great interest, no incompatibility has been characterized at the...
18.
Baudat F, Buard J, Grey C, de Massy B
Med Sci (Paris) . 2011 Dec; 27(12):1053-5. PMID: 22192738
No abstract available.
19.
Grey C, Barthes P, Chauveau-Le Friec G, Langa F, Baudat F, de Massy B
PLoS Biol . 2011 Oct; 9(10):e1001176. PMID: 22028627
Meiotic recombination generates reciprocal exchanges between homologous chromosomes (also called crossovers, COs) that are essential for proper chromosome segregation during meiosis and are a major source of genome diversity by...
20.
Kauppi L, Barchi M, Baudat F, Romanienko P, Keeney S, Jasin M
Science . 2011 Feb; 331(6019):916-20. PMID: 21330546
Meiosis requires that each chromosome find its homologous partner and undergo at least one crossover. X-Y chromosome segregation hinges on efficient crossing-over in a very small region of homology, the...