Frederic Baudat
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Explore the profile of Frederic Baudat including associated specialties, affiliations and a list of published articles.
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32
Citations
1864
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Recent Articles
1.
Raynaud M, Sanna P, Joseph J, Clement J, Imai Y, Lareyre J, et al.
PLoS Biol
. 2025 Jan;
23(1):e3002950.
PMID: 39761307
In many eukaryotes, meiotic recombination occurs preferentially at discrete sites, called recombination hotspots. In various lineages, recombination hotspots are located in regions with promoter-like features and are evolutionarily stable. Conversely,...
2.
Zainu A, Dupaigne P, Bouchouika S, Cau J, Clement J, Auffret P, et al.
Nat Commun
. 2024 Aug;
15(1):7015.
PMID: 39147779
During meiosis, nucleoprotein filaments of the strand exchange proteins RAD51 and DMC1 are crucial for repairing SPO11-generated DNA double-strand breaks (DSBs) by homologous recombination (HR). A balanced activity of positive...
3.
Cau J, Dal Toe L, Zainu A, Baudat F, Robert T
Methods Mol Biol
. 2024 Feb;
2770:263-285.
PMID: 38351458
Immunocytochemical analysis of meiotic proteins on mouse chromosome spreads is one method of choice to study prophase I chromosome organization and homologous recombination. In recent decades, the development of microscopic...
4.
Baudat F, de Massy B
Science
. 2023 Nov;
382(6674):997-998.
PMID: 38033058
Multiple pathways generate mutations at sites of meiotic recombination in humans.
5.
Imai Y, Biot M, Clement J, Teragaki M, Urbach S, Robert T, et al.
Elife
. 2020 Oct;
9.
PMID: 33047671
Meiotic recombination starts with the formation of DNA double-strand breaks (DSBs) at specific genomic locations that correspond to PRDM9-binding sites. The molecular steps occurring from PRDM9 binding to DSB formation...
6.
Legeai F, Santos B, Robin S, Bretaudeau A, Dikow R, Lemaitre C, et al.
BMC Biol
. 2020 Jul;
18(1):89.
PMID: 32703219
Background: Polydnaviruses (PDVs) are mutualistic endogenous viruses inoculated by some lineages of parasitoid wasps into their hosts, where they facilitate successful wasp development. PDVs include the ichnoviruses and bracoviruses that...
7.
Baudat F, de Massy B, Veyrunes F
Chromosoma
. 2019 Mar;
128(3):397-411.
PMID: 30919035
Eutherian mammals have an extremely conserved sex-determining system controlled by highly differentiated sex chromosomes. Females are XX and males XY, and any deviation generally leads to infertility, mainly due to...
8.
Grey C, Baudat F, de Massy B
PLoS Genet
. 2018 Aug;
14(8):e1007479.
PMID: 30161134
During meiosis, maternal and paternal chromosomes undergo exchanges by homologous recombination. This is essential for fertility and contributes to genome evolution. In many eukaryotes, sites of meiotic recombination, also called...
9.
Diagouraga B, Clement J, Duret L, Kadlec J, de Massy B, Baudat F
Mol Cell
. 2018 Feb;
69(5):853-865.e6.
PMID: 29478809
The programmed formation of hundreds of DNA double-strand breaks (DSBs) is essential for proper meiosis and fertility. In mice and humans, the location of these breaks is determined by the...
10.
Imai Y, Baudat F, Taillepierre M, Stanzione M, Toth A, de Massy B
Chromosoma
. 2017 May;
126(6):681-695.
PMID: 28527011
PR domain-containing protein 9 (PRDM9) is a major regulator of the localization of meiotic recombination hotspots in the human and mouse genomes. This role involves its DNA-binding domain, which is...