Franziska R Traube
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Explore the profile of Franziska R Traube including associated specialties, affiliations and a list of published articles.
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17
Citations
179
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Recent Articles
1.
Reinhardt T, El Harraoui Y, Rothemann A, Jauch A, Muller-Deubert S, Kollen M, et al.
Angew Chem Int Ed Engl
. 2025 Feb;
:e202421424.
PMID: 39964703
Fluoroquinolones (FQs) are an important class of potent broad-spectrum antibiotics. However, their general use is more and more limited by adverse side effects. While general mechanisms for the fluoroquinolone-associated disability...
2.
Aumer T, Dather M, Bergmayr L, Kartika S, Zeng T, Ge Q, et al.
Life Sci Alliance
. 2024 Jun;
7(9).
PMID: 38906675
Decitabine and azacytidine are considered as epigenetic drugs that induce DNA methyltransferase (DNMT)-DNA crosslinks, resulting in DNA hypomethylation and damage. Although they are already applied against myeloid cancers, important aspects...
3.
Braun J, Hu Y, Jauch A, Gronauer T, Mergner J, Bach N, et al.
JACS Au
. 2024 May;
4(5):1833-1840.
PMID: 38818080
Neocarzilin (NCA) is a natural product exhibiting potent antimigratory as well as antiproliferative effects. While vesicle amine transport protein 1 (VAT-1) was previously shown to inhibit migration upon NCA binding,...
4.
Cao X, Huber S, Ahari A, Traube F, Seifert M, Oakes C, et al.
Genome Med
. 2024 May;
16(1):70.
PMID: 38769532
Background: Rare oncogenic driver events, particularly affecting the expression or splicing of driver genes, are suspected to substantially contribute to the large heterogeneity of hematologic malignancies. However, their identification remains...
5.
Aumer T, Gremmelmaier C, Runtsch L, Pforr J, Yesiltac G, Kaiser S, et al.
Clin Epigenetics
. 2022 Sep;
14(1):113.
PMID: 36089606
Azacytidine (AzaC) and decitabine (AzadC) are cytosine analogs that covalently trap DNA methyltransferases, which place the important epigenetic mark 5-methyl-2'-deoxycytidine by methylating 2'-deoxycytidine (dC) at the C5 position. AzaC and...
6.
Traube F, Stern M, Tolke A, Rudelius M, Mejias-Perez E, Raddaoui N, et al.
Angew Chem Int Ed Engl
. 2022 Jul;
61(38):e202204556.
PMID: 35802496
The emergence of more transmissible or aggressive variants of SARS-CoV-2 requires the development of antiviral medication that is quickly adjustable to evolving viral escape mutations. Here we report the synthesis...
7.
Traube F, Bras N, Roos W, Sommermann C, Diehl T, Mayer R, et al.
Chemistry
. 2022 Mar;
28(26):e202200640.
PMID: 35285586
5-Aza-2'-deoxycytidine (Decitabine, AzadC) is a nucleoside analogue, which is in clinical use to treat patients with myelodysplastic syndrome or acute myeloid leukemia. Its mode of action is unusual because the...
8.
Panosyan H, Traube F, Brandmayr C, Wagner M, Carell T
Extremophiles
. 2022 Feb;
26(1):11.
PMID: 35122547
Transfer RNAs (tRNAs) are the most ancient RNA molecules in the cell, modification pattern of which is linked to phylogeny. The aim of this study was to determine the tRNA...
9.
Traube F, Ozdemir D, Sahin H, Scheel C, Gluck A, Geserich A, et al.
Nat Commun
. 2021 Jul;
12(1):4100.
PMID: 34215750
Tet3 is the main α-ketoglutarate (αKG)-dependent dioxygenase in neurons that converts 5-methyl-dC into 5-hydroxymethyl-dC and further on to 5-formyl- and 5-carboxy-dC. Neurons possess high levels of 5-hydroxymethyl-dC that further increase...
10.
Traube F, Schiffers S, Carell T
Methods Mol Biol
. 2021 May;
2272:77-94.
PMID: 34009610
The amount of 5-methyl-2'-deoxycytidine (mdC) and its oxidized derivatives 5-hydroxymethyl-dC (hmdC), 5-formyl-dC (fdC), and 5-carboxy-dC (cadC) inside mammalian cells provides valuable information concerning cellular state and fate. LC-MS methods enable...