Franziska Boess
Overview
Explore the profile of Franziska Boess including associated specialties, affiliations and a list of published articles.
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Articles
24
Citations
410
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Recent Articles
1.
Zampaloni C, Mattei P, Bleicher K, Winther L, Thate C, Bucher C, et al.
Nature
. 2024 Jul;
631(8022):E17.
PMID: 38992182
No abstract available.
2.
Zampaloni C, Mattei P, Bleicher K, Winther L, Thate C, Bucher C, et al.
Nature
. 2024 Jan;
625(7995):566-571.
PMID: 38172634
Carbapenem-resistant Acinetobacter baumannii (CRAB) has emerged as a major global pathogen with limited treatment options. No new antibiotic chemical class with activity against A. baumannii has reached patients in over...
3.
Nudischer R, Renggli K, Bertinetti-Lapatki C, Hoflack J, Flint N, Sewing S, et al.
Toxicol Sci
. 2020 May;
176(2):329-342.
PMID: 32458970
Basimglurant (RG7090), a small molecule under development to treat certain forms of depression, demonstrated foci of altered hepatocytes in a long-term rodent-toxicity study. Additional evidence pointed toward the activation of...
4.
Sewing S, Minz T, Boess F
Methods Mol Biol
. 2019 Aug;
2036:249-259.
PMID: 31410802
The mechanisms of antisense oligonucleotide-induced liver toxicity are still poorly understood. Assessment of the hepatic safety profile is currently mostly investigated directly in rodent studies. A predictive preclinical in vitro...
5.
Kratochwil N, Triyatni M, Mueller M, Klammers F, Leonard B, Turley D, et al.
J Pharmacol Exp Ther
. 2018 Feb;
365(2):237-248.
PMID: 29453199
Long-term in vitro liver models are now widely explored for human hepatic metabolic clearance prediction, enzyme phenotyping, cross-species metabolism, comparison of low clearance drugs, and induction studies. Here, we present...
6.
Zhang J, Kung E, Boess F, Certa U, Ebeling M
BMC Genomics
. 2017 May;
18(1):337.
PMID: 28464836
No abstract available.
7.
Boess F, Lenz B, Funk J, Niederhauser U, Bassett S, Zhang J, et al.
Toxicology
. 2017 Feb;
379:48-61.
PMID: 28174063
Foci of altered hepatocytes (FAH) are considered putative, pre-neoplastic lesions that can occur spontaneously in aging rodents, but can also be induced by chemicals or drugs. Progression of FAH to...
8.
Berger B, Donzelli M, Maseneni S, Boess F, Roth A, Krahenbuhl S, et al.
Front Pharmacol
. 2016 Dec;
7:443.
PMID: 27917125
Currently used hepatocyte cell systems for assessment of drug metabolism include hepatoma cell lines and primary human hepatocyte (PHH) cultures. We investigated the suitability of the validated Basel phenotyping cocktail...
9.
Sewing S, Boess F, Moisan A, Bertinetti-Lapatki C, Minz T, Hedtjaern M, et al.
PLoS One
. 2016 Jul;
11(7):e0159431.
PMID: 27442522
Single stranded oligonucleotides (SSO) represent a novel therapeutic modality that opens new space to address previously undruggable targets. In spite of their proven efficacy, the development of promising SSO drug...
10.
Teppner M, Boess F, Ernst B, Pahler A
Drug Metab Dispos
. 2016 Jan;
44(4):560-9.
PMID: 26817949
The nonsteroidal androgen-receptor antagonist flutamide is associated with hepatic injury. Oxidative stress and reactive metabolite formation are considered contributing factors to liver toxicity. Here we have used flutamide as a...