Frans J J de Kanter
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Explore the profile of Frans J J de Kanter including associated specialties, affiliations and a list of published articles.
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47
Citations
286
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Recent Articles
1.
Wijtmans M, Scholten D, Roumen L, Canals M, Custers H, Glas M, et al.
J Med Chem
. 2012 Nov;
55(23):10572-83.
PMID: 23150943
The G protein-coupled chemokine receptor CXCR3 plays a role in numerous inflammatory events. The endogenous ligands for the chemokine receptors are peptides, but in this study we disclose small-molecule ligands...
2.
Kruithof A, Ploeger M, Janssen E, Helliwell M, de Kanter F, Ruijter E, et al.
Molecules
. 2012 Feb;
17(2):1675-85.
PMID: 22318323
Non-fused 3,6-dihydro-2H-1,3-thiazine-2-thiones constitute a so far rather unexplored class of compounds, with the latest report dating back more than two decades. Thiazine-2-thiones contain an endocyclic dithiocarbamate group, which is often...
3.
Edink E, Akdemir A, Jansen C, van Elk R, Zuiderveld O, de Kanter F, et al.
Bioorg Med Chem Lett
. 2012 Jan;
22(3):1448-54.
PMID: 22243960
Using structure-based optimization procedures on in silico hits, dibenzosuberyl- and benzoate substituted tropines were designed as ligands for acetylcholine-binding protein (AChBP). This protein is a homolog to the ligand binding...
4.
Bertini F, Lyaskovskyy V, Timmer B, de Kanter F, Lutz M, Ehlers A, et al.
J Am Chem Soc
. 2011 Dec;
134(1):201-4.
PMID: 22185581
Geminal frustrated Lewis pairs (FLPs) are expected to exhibit increased reactivity when the donor and acceptor sites are perfectly aligned. This is shown for reactions of the nonfluorinated FLP tBu(2)PCH(2)BPh(2)...
5.
Znabet A, Blanken S, Janssen E, de Kanter F, Helliwell M, Turner N, et al.
Org Biomol Chem
. 2011 Dec;
10(5):941-4.
PMID: 22179495
An efficient combination of MAO-N-catalyzed desymmetrization of cyclic meso-amines with Ugi-Smiles multicomponent chemistry produced optically pure N-aryl proline amides. This method represents the first report of a fully asymmetric Ugi-Smiles...
6.
Van Baelen G, Kuijer S, Rycek L, Sergeyev S, Janssen E, de Kanter F, et al.
Chemistry
. 2011 Nov;
17(52):15039-44.
PMID: 22125085
Compared with the widespread use of carbonylative Pd-catalyzed cross-coupling reactions, similar reactions involving isocyanide insertion are almost virgin territory. We investigated the intramolecular imidoylative cross-coupling of N-(2-bromoaryl)amidines, leading to 4-aminoquinazolines....
7.
Vlaar T, Ruijter E, Znabet A, Janssen E, de Kanter F, Maes B, et al.
Org Lett
. 2011 Nov;
13(24):6496-9.
PMID: 22085248
Palladium-catalyzed cross-coupling of a wide range of substituted o-(pseudo)halobenzoates and hydrazines with isocyanide insertion followed by lactamization efficiently affords 4-aminophthalazin-1(2H)-ones that are difficult to obtain regioselectively by classical methods.
8.
Rea V, Dragovic S, Boerma J, de Kanter F, Vermeulen N, Commandeur J
Drug Metab Dispos
. 2011 Sep;
39(12):2411-20.
PMID: 21890734
In the present study, a site-saturation mutagenesis library of drug-metabolizing CYP102A1 M11H with all 20 amino acids at position 87 was applied as a biocatalyst for the production of stable...
9.
Marques L, Maada I, de Kanter F, Lingeman H, Irth H, Niessen W, et al.
J Pharm Biomed Anal
. 2011 Feb;
55(1):85-92.
PMID: 21300511
Galantamine hydrobromide was subjected to different stress conditions (acidic, alkaline, thermal, photolytic and oxidative). Degradation was found to occur under acidic, photolytic and oxidative conditions, while the drug was stable...
10.
Znabet A, Zonneveld J, Janssen E, de Kanter F, Helliwell M, Turner N, et al.
Chem Commun (Camb)
. 2010 Sep;
46(41):7706-8.
PMID: 20871902
We have combined the biocatalytic desymmetrization of 3,4-cis-substituted meso-pyrrolidines with an Ugi-type multicomponent reaction followed in situ by a Pictet-Spengler-type cyclization reaction sequence for the rapid asymmetric synthesis of alkaloid-like...