Frans A Kuypers
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Explore the profile of Frans A Kuypers including associated specialties, affiliations and a list of published articles.
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94
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1920
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Recent Articles
1.
Ericsson A, Richard D, Wilker E, Lancia Jr D, Fessler S, Troccolo P, et al.
Exp Hematol
. 2024 Nov;
141():104673.
PMID: 39549740
Anemia in patients with sickle cell disease (SCD) increases 2,3-diphosphoglycerate (2,3-DPG), decreasing hemoglobin-oxygen (HbO) affinity to improve oxygen offloading and promote hemoglobin polymerization (sickling) of red blood cells (RBCs). We...
2.
Saraf S, Hagar R, Idowu M, Osunkwo I, Cruz K, Kuypers F, et al.
Blood Adv
. 2024 Apr;
8(16):4459-4475.
PMID: 38640200
Etavopivat is an investigational, once daily, oral, selective erythrocyte pyruvate kinase (PKR) activator. A multicenter, randomized, placebo-controlled, double-blind, 3-part, phase 1 study was conducted to characterize the safety and clinical...
3.
The RoxyScan is a novel measurement of red blood cell deformability under oxidative and shear stress
Larkin S, Hernandez C, van Beers E, van Wijk R, Kuypers F
Sci Rep
. 2024 Mar;
14(1):6344.
PMID: 38491086
Exposure to both oxidative and shear stress, a condition that the red blood cell (RBC) continuously experiences in the circulation in vivo can be mimicked in a Couette type viscometer...
4.
Costello J, Koster J, Silva B, Worthy H, Schrader T, Hacker C, et al.
J Biol Chem
. 2023 Jul;
299(8):105013.
PMID: 37414147
Peroxisomes and the endoplasmic reticulum (ER) are intimately linked subcellular organelles, physically connected at membrane contact sites. While collaborating in lipid metabolism, for example, of very long-chain fatty acids (VLCFAs)...
5.
Stookey J, Paulweber B, Felder T, Lang F, Haussinger D, Killilea D, et al.
Paracelsus Proc Exp Med
. 2023 Jun;
2(1):41-66.
PMID: 37304678
Background/aims: Cells adapt to chronic extracellular hypotonicity by altering metabolism. Corresponding effects of sustained hypotonic exposure at the whole-person level remain to be confirmed and characterized in clinical and population-based...
6.
Phan V, Hershenson J, Caldarera L, Larkin S, Wheeler K, Cortez A, et al.
Pediatr Blood Cancer
. 2023 May;
70(8):e30423.
PMID: 37247190
Background: Individuals with sickle cell anemia (SCA) exhibit decreased exercise capacity. Anemia limits oxygen-carrying capacity and affects cardiopulmonary fitness. The drug voxelotor raises hemoglobin in SCA. We hypothesized that voxelotor...
7.
Vissa M, Larkin S, Vichinsky E, Kuypers F, Soupene E
Exp Biol Med (Maywood)
. 2023 Mar;
248(10):897-907.
PMID: 36941786
Intravascular hemolysis results in the release of cell-free hemoglobin and heme in plasma. In sickle cell disease, the fragility of the sickle red blood cell leads to chronic hemolysis, which...
8.
Soupene E, Kuypers F
Biomolecules
. 2022 Dec;
12(12).
PMID: 36551154
The transfer of acyl chains to proteins and lipids from acyl-CoA donor molecules is achieved by the actions of diverse enzymes and proteins, including the acyl-CoA binding domain-containing protein ACBD6....
9.
Killilea D, Kuypers F, Larkin S, Schultz K
PLoS One
. 2022 Nov;
17(11):e0278350.
PMID: 36449486
Anemia is a continuing global public health concern and a priority for international action. The prevalence of anemia is estimated from the hemoglobin (Hb) levels within target populations, yet the...
10.
Walter P, Hohman L, Rokeby A, Lum J, Hagar R, Lavrisha L, et al.
Complement Ther Med
. 2022 Jul;
70:102856.
PMID: 35843474
Objectives: L-Glutamine was FDA-approved for sickle cell disease (SCD) in 2017, yet the mechanism(s)-of-action are poorly understood. This study investigates the potential activation of autophagy as a previously unexplored mechanism-of-benefit....