Sandra Larkin
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Explore the profile of Sandra Larkin including associated specialties, affiliations and a list of published articles.
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18
Citations
321
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Recent Articles
1.
Ericsson A, Richard D, Wilker E, Lancia Jr D, Fessler S, Troccolo P, et al.
Exp Hematol
. 2024 Nov;
141():104673.
PMID: 39549740
Anemia in patients with sickle cell disease (SCD) increases 2,3-diphosphoglycerate (2,3-DPG), decreasing hemoglobin-oxygen (HbO) affinity to improve oxygen offloading and promote hemoglobin polymerization (sickling) of red blood cells (RBCs). We...
2.
Morris C, Kuypers F, Hagar R, Larkin S, Lavrisha L, Saulys A, et al.
Complement Ther Med
. 2022 Jan;
64:102803.
PMID: 35032556
Objectives: L-Glutamine is FDA-approved for sickle cell disease (SCD), yet the mechanism(s)-of-action are poorly understood. We performed a pharmacokinetics (pK) study to determine the metabolic fate of glutamine supplementation on...
3.
Michlitsch J, Larkin S, Vichinsky E, Kuypers F
Exp Biol Med (Maywood)
. 2019 Jun;
244(10):850-854.
PMID: 31161774
No abstract available.
4.
Goktas P, Sukharevsky I, Larkin S, Kuypers F, Yalcin O, Altintas A
Cytometry A
. 2019 Apr;
95(5):488-498.
PMID: 30980696
Red blood cells (RBCs) from sickle cell patients exposed to a low oxygen tension reveal highly heterogeneous cell morphologies due to the polymerization of sickle hemoglobin (HbS). We show that...
5.
Hoppe C, Jacob E, Styles L, Kuypers F, Larkin S, Vichinsky E
Br J Haematol
. 2017 Apr;
177(4):620-629.
PMID: 28369718
Sickle cell anaemia (SCA) is a progressive vascular disease characterized by episodic vaso-occlusive pain. Despite the broad impact of inflammation on acute and chronic clinical manifestations of SCA, no directed...
6.
Cabrales P, Scicinski J, Reid T, Kuypers F, Larkin S, Fens M, et al.
Med Oncol
. 2016 May;
33(7):63.
PMID: 27229330
The therapeutic potential of epi-immunotherapeutic anticancer agent RRx-001 in cancer has been validated with preclinical and clinical studies, since RRx-001 has successfully completed a phase 1 trial and multiple single-agent...
7.
Morris C, Kim H, Klings E, Wood J, Porter J, Trachtenberg F, et al.
Br J Haematol
. 2015 Apr;
169(6):887-98.
PMID: 25907665
Pulmonary hypertension (PH) commonly develops in thalassaemia syndromes, but is poorly characterized. The goal of this study was to provide a comprehensive description of the cardiopulmonary and biological profile of...
8.
Marsh A, Schiffelers R, Kuypers F, Larkin S, Gildengorin G, van Solinge W, et al.
Br J Haematol
. 2014 Sep;
168(1):135-8.
PMID: 25196812
Osteonecrosis of the femoral head (ONFH) is a common complication of sickle cell disease (SCD). To examine the association between microparticles and ONFH in SCD, we compared plasma microparticle levels...
9.
Singer S, Kuypers F, Fineman J, Gildengorin G, Larkin S, Sweeters N, et al.
Ann Hematol
. 2014 Mar;
93(7):1139-48.
PMID: 24577514
A high tricuspid regurgitant jet velocity (TRV) signifies a risk for or established pulmonary hypertension (PH), which is a serious complication in thalassemia patients. The underlying pathophysiology in thalassemia subgroups...
10.
Stookey J, Klein A, Hamer J, Chi C, Higa A, Ng V, et al.
Physiol Rep
. 2013 Dec;
1(5):e00117.
PMID: 24303184
Biomarkers of chronic cell hydration status are needed to determine whether chronic hyperosmotic stress increases chronic disease risk in population-representative samples. In vitro, cells adapt to chronic hyperosmotic stress by...