Frank Guarnieri
Overview
Explore the profile of Frank Guarnieri including associated specialties, affiliations and a list of published articles.
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Articles
19
Citations
335
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Recent Articles
1.
Gazgalis D, Cantwell L, Xu Y, Thakur G, Cui M, Guarnieri F, et al.
Int J Mol Sci
. 2022 Sep;
23(18).
PMID: 36142730
G protein-gated inwardly rectifying K (GIRK) channels form highly active heterotetramers in the body, such as in neurons (GIRK1/GIRK2 or GIRK1/2) and heart (GIRK1/GIRK4 or GIRK1/4). Based on three-dimensional atomic...
2.
Guarnieri F, Kulp Jr J, Kulp 3rd J, Cloudsdale I
PLoS One
. 2019 Dec;
14(12):e0225780.
PMID: 31805108
PCSK9 is a protein secreted by the liver that binds to the low-density lipoprotein receptor (LDLR), causing LDLR internalization, decreasing the clearance of circulating LDL particles. Mutations in PCSK9 that...
3.
Kulp 3rd J, Cloudsdale I, Kulp Jr J, Guarnieri F
PLoS One
. 2017 Aug;
12(8):e0183327.
PMID: 28837642
Chemically diverse fragments tend to collectively bind at localized sites on proteins, which is a cornerstone of fragment-based techniques. A central question is how general are these strategies for predicting...
4.
Guarnieri F
Vitam Horm
. 2017 Jun;
105:19-37.
PMID: 28629518
Amgen solved the high-resolution cocrystal structure of erythropoietin (EPO) bound to the extracellular part of the receptor (EPOR) in 1998, which reveals that the EPO-EPOR interaction surface is formed by...
5.
Cloudsdale I, Dickson Jr J, Barta T, Grella B, Smith E, Kulp 3rd J, et al.
Bioorg Med Chem
. 2017 Jun;
25(15):3947-3963.
PMID: 28601508
We have applied simulated annealing of chemical potential (SACP) to a diverse set of ∼150 very small molecules to provide insights into new interactions in the binding pocket of human...
6.
Guarnieri F
Methods Mol Biol
. 2015 Feb;
1289:211-26.
PMID: 25709042
The MAPK p38 became a focal point of inflammatory research when it was recognized that it played a key role in the production of the pro-inflammatory molecules TNF-alpha, IL-beta, and...
7.
Guarnieri F
Methods Mol Biol
. 2015 Feb;
1289:185-210.
PMID: 25709041
Erythropoietin (EPO) is a protein made by the kidneys in response to low red blood cell count that is secreted into the bloodstream and binds to a receptor on hematopoietic...
8.
Kulp 3rd J, Blumenthal S, Wang Q, Bryan R, Guarnieri F
J Comput Aided Mol Des
. 2012 Feb;
26(5):583-94.
PMID: 22290624
The success of molecular fragment-based design depends critically on the ability to make predictions of binding poses and of affinity ranking for compounds assembled by linking fragments. The SAMPL3 Challenge...
9.
Moffett K, Konteatis Z, Nguyen D, Shetty R, Ludington J, Fujimoto T, et al.
Bioorg Med Chem Lett
. 2011 Oct;
21(23):7155-65.
PMID: 22014550
Discovery of a new class of DFG-out p38α kinase inhibitors with no hinge interaction is described. A computationally assisted, virtual fragment-based drug design (vFBDD) platform was utilized to identify novel...
10.
Bradbury M, Stump D, Guarnieri F, Berk P
J Mol Biol
. 2011 Aug;
412(3):412-22.
PMID: 21803047
Molecular interactions are necessary for proteins to perform their functions. The identification of a putative plasma membrane fatty acid transporter as mitochondrial aspartate aminotransferase (mAsp-AT) indicated that the protein must...