Frank Erdmann
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Explore the profile of Frank Erdmann including associated specialties, affiliations and a list of published articles.
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Articles
63
Citations
800
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Recent Articles
1.
Meinhard S, Erdmann F, Lucas H, Krabbes M, Kruger S, Wolk C, et al.
Pharmaceutics
. 2025 Jan;
17(1).
PMID: 39861674
Background/objectives: Bringing small interfering RNA (siRNA) into the cell cytosol to achieve specific gene silencing is an attractive but also very challenging option for improved therapies. The first step for...
2.
Ibrahim H, Guo M, Hilscher S, Erdmann F, Schmidt M, Schutkowski M, et al.
Bioorg Chem
. 2024 Oct;
153:107887.
PMID: 39423771
Class I HDACs are considered promising targets for cancer due to their role in epigenetic modifications. The main challenges in developing a new, potent and non-toxic class I HDAC inhibitor...
3.
Lang M, Ganapathy U, Mann L, Seidel R, Goddard R, Erdmann F, et al.
ChemMedChem
. 2024 Feb;
19(6):e202300593.
PMID: 38329388
Nα-aroyl-N-aryl-phenylalanine amides (AAPs) are RNA polymerase inhibitors with activity against Mycobacterium tuberculosis and non-tuberculous mycobacteria. We observed that AAPs rapidly degrade in microsomal suspensions, suggesting that avoiding hepatic metabolism is...
4.
Alfayomy A, Ashry R, Kansy A, Sarnow A, Erdmann F, Schmidt M, et al.
Eur J Med Chem
. 2024 Feb;
267:116167.
PMID: 38308949
The Ataxia telangiectasia and RAD3-related (ATR) kinase is a key regulator of DNA replication stress responses and DNA-damage checkpoints. Several potent and selective ATR inhibitors are reported and four of...
5.
Kendzia S, Franke S, Krohler T, Golob-Schwarzl N, Schweiger C, Toeglhofer A, et al.
Mol Cancer
. 2023 May;
22(1):89.
PMID: 37248468
Aim: Chemoresistance is a major cause of treatment failure in colorectal cancer (CRC) therapy. In this study, the impact of the IGF2BP family of RNA-binding proteins on CRC chemoresistance was...
6.
Sun P, Wang J, Khan K, Yang W, Ng B, Ilment N, et al.
J Med Chem
. 2022 Nov;
65(24):16313-16337.
PMID: 36449385
Histone deacetylases (HDACs) are epigenetic regulators and additionally control the activity of non-histone substrates. We recently demonstrated that inhibition of HDAC8 overexpressed in various of cancers reduces hepatocellular carcinoma tumorigenicity...
7.
Darwish S, Ghazy E, Heimburg T, Herp D, Zeyen P, Salem-Altintas R, et al.
Int J Mol Sci
. 2022 Jul;
23(14).
PMID: 35886887
In addition to involvement in epigenetic gene regulation, histone deacetylases (HDACs) regulate multiple cellular processes through mediating the activity of non-histone protein substrates. The knockdown of HDAC8 isozyme is associated...
8.
Giselbrecht J, Pinnapireddy S, Alioglu F, Sami H, Sedding D, Erdmann F, et al.
Small
. 2022 Mar;
18(18):e2107768.
PMID: 35355412
Formulations based on ionizable amino-lipids have been put into focus as nucleic acid delivery systems. Recently, the in vitro efficacy of the lipid formulation OH4:DOPE has been explored. However, in...
9.
Zeyen P, Zeyn Y, Herp D, Mahmoudi F, Yesiloglu T, Erdmann F, et al.
Eur J Med Chem
. 2022 Mar;
234:114272.
PMID: 35306288
Histone deacetylases (HDACs) are a family of 18 epigenetic modifiers that fall into 4 classes. Histone deacetylase inhibitors (HDACi) are valid tools to assess HDAC functions. HDAC6 and HDAC10 belong...
10.
Ibrahim H, Abdelsalam M, Zeyn Y, Zessin M, Mustafa A, Fischer M, et al.
Int J Mol Sci
. 2022 Jan;
23(1).
PMID: 35008795
Class I histone deacetylases (HDACs) are key regulators of cell proliferation and they are frequently dysregulated in cancer cells. We report here the synthesis of a novel series of class-I...