Francoise Ischer
Overview
Explore the profile of Francoise Ischer including associated specialties, affiliations and a list of published articles.
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15
Citations
1401
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Recent Articles
1.
Pierrehumbert A, Ischer F, Coste A
Front Microbiol
. 2017 Jun;
8:873.
PMID: 28559890
The commensal fungus is the major cause of fungal systemic infection in immuno-compromised patients, with a mortality rate approaching 50% in the case of bloodstream infections. There is therefore a...
2.
Delarze E, Ischer F, Sanglard D, Coste A
Virulence
. 2015 Aug;
6(7):684-93.
PMID: 26305489
For the past 10 years, mini-host models and in particular the greater wax moth Galleria mellonella have tended to become a surrogate for murine models of fungal infection mainly due...
3.
Amorim-Vaz S, Delarze E, Ischer F, Sanglard D, Coste A
Front Microbiol
. 2015 May;
6:367.
PMID: 25999923
The aim of the present study was to identify Candida albicans transcription factors (TFs) involved in virulence. Although mice are considered the gold-standard model to study fungal virulence, mini-host infection...
4.
Molecular mechanisms of drug resistance in clinical Candida species isolated from Tunisian hospitals
Eddouzi J, Parker J, Vale-Silva L, Coste A, Ischer F, Kelly S, et al.
Antimicrob Agents Chemother
. 2013 May;
57(7):3182-93.
PMID: 23629718
Antifungal resistance of Candida species is a clinical problem in the management of diseases caused by these pathogens. In this study we identified from a collection of 423 clinical samples...
5.
Vale-Silva L, Ischer F, LeibundGut-Landmann S, Sanglard D
Infect Immun
. 2013 Mar;
81(5):1709-20.
PMID: 23460523
Candida glabrata is an emerging opportunistic pathogen that is known to develop resistance to azole drugs due to increased drug efflux. The mechanism consists of CgPDR1-mediated upregulation of ATP-binding cassette...
6.
Vandeputte P, Pradervand S, Ischer F, Coste A, Ferrari S, Harshman K, et al.
Eukaryot Cell
. 2012 May;
11(7):916-31.
PMID: 22581526
The identification of novel transcription factors associated with antifungal response may allow the discovery of fungus-specific targets for new therapeutic strategies. A collection of 241 Candida albicans transcriptional regulator mutants...
7.
Vandeputte P, Ischer F, Sanglard D, Coste A
PLoS One
. 2011 Nov;
6(10):e26962.
PMID: 22073120
The incidence of fungal infections in immuno-compromised patients increased considerably over the last 30 years. New treatments are therefore needed against pathogenic fungi. With Candida albicans as a model, study...
8.
MacCallum D, Coste A, Ischer F, Jacobsen M, Odds F, Sanglard D
Antimicrob Agents Chemother
. 2010 Jan;
54(4):1476-83.
PMID: 20086148
Principal mechanisms of resistance to azole antifungals include the upregulation of multidrug transporters and the modification of the target enzyme, a cytochrome P450 (Erg11) involved in the 14alpha-demethylation of ergosterol....
9.
Ferrari S, Ischer F, Calabrese D, Posteraro B, Sanguinetti M, Fadda G, et al.
PLoS Pathog
. 2009 Jan;
5(1):e1000268.
PMID: 19148266
CgPdr1p is a Candida glabrata Zn(2)-Cys(6) transcription factor involved in the regulation of the ABC-transporter genes CgCDR1, CgCDR2, and CgSNQ2, which are mediators of azole resistance. Single-point mutations in CgPDR1...
10.
Coste A, Ramsdale M, Ischer F, Sanglard D
Microbiology (Reading)
. 2008 May;
154(Pt 5):1491-1501.
PMID: 18451058
One of the mediators of pleiotropic drug resistance in Saccharomyces cerevisiae is the ABC-transporter gene PDR5. This gene is regulated by at least two transcription factors with Zn(2)-Cys(6) finger DNA-binding...