Francesca Sacco
Overview
Explore the profile of Francesca Sacco including associated specialties, affiliations and a list of published articles.
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46
Citations
1413
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Recent Articles
1.
Tiano S, Landi N, Marano V, Ragucci S, Bianco G, Cacchiarelli D, et al.
Int J Biol Macromol
. 2024 Sep;
280(Pt 1):135700.
PMID: 39288862
SARS-CoV-2 pandemic clearly demonstrated the lack of preparation against novel and emerging viral diseases. This prompted an enormous effort to identify antivirals to curb viral spread and counteract future pandemics....
2.
Venafra V, Sacco F, Perfetto L
NPJ Syst Biol Appl
. 2024 Aug;
10(1):95.
PMID: 39179556
Unraveling how cellular signaling is remodeled upon perturbation is crucial for understanding disease mechanisms and identifying potential drug targets. In this pursuit, computational tools generating mechanistic hypotheses from multi-omics data...
3.
Massacci G, Venafra V, Zwiebel M, Wahle M, Cerroni R, Bissacco J, et al.
Neurobiol Dis
. 2024 Aug;
200:106622.
PMID: 39097034
The complexity and heterogeneity of PD necessitate advanced diagnostic and prognostic tools to elucidate its molecular mechanisms accurately. In this study, we addressed this challenge by conducting a pilot phospho-proteomic...
4.
Latini S, Venafra V, Massacci G, Bica V, Graziosi S, Pugliese G, et al.
Elife
. 2024 Apr;
12.
PMID: 38564252
Currently, the identification of patient-specific therapies in cancer is mainly informed by personalized genomic analysis. In the setting of acute myeloid leukemia (AML), patient-drug treatment matching fails in a subset...
5.
Massacci G, Perfetto L, Sacco F
Br J Cancer
. 2023 Oct;
129(11):1707-1716.
PMID: 37898722
The Cyclin-dependent kinase 1, as a serine/threonine protein kinase, is more than a cell cycle regulator as it was originally identified. During the last decade, it has been shown to...
6.
Cerofolini L, Ravera E, Fischer C, Trovato A, Sacco F, Palinsky W, et al.
Anal Chem
. 2023 Jun;
95(24):9199-9206.
PMID: 37278511
The assessment of the higher-order structure (HOS) by NMR is a powerful methodology to characterize the structural features of biologics. Forced oxidative stress studies are used to investigate the stability...
7.
Pugliese G, Venafra V, Bica V, Massacci G, Latini S, Graziosi S, et al.
Leukemia
. 2023 Mar;
37(5):1151-1155.
PMID: 36966261
No abstract available.
8.
Massacci G, Venafra V, Latini S, Bica V, Pugliese G, Graziosi S, et al.
Leukemia
. 2022 Dec;
37(2):288-297.
PMID: 36509894
The insertion site of the internal tandem duplications (ITDs) in the FLT3 gene affects the sensitivity to tyrosine kinase inhibitors (TKIs) therapy in acute myeloid leukemia (AML). Patients with the...
9.
10.
Contadini C, Ferri A, Di Martile M, Cirotti C, Del Bufalo D, De Nicola F, et al.
Cell Death Differ
. 2022 Dec;
30(2):417-428.
PMID: 36460775
Caspase-8 is a cysteine protease that plays an essential role in apoptosis. Consistently with its canonical proapoptotic function, cancer cells may genetically or epigenetically downregulate its expression. Unexpectedly, Caspase-8 is...