Francesca Sacco
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Explore the profile of Francesca Sacco including associated specialties, affiliations and a list of published articles.
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Articles
46
Citations
1413
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Recent Articles
11.
Di Lorenzo G, Iavarone F, Maddaluno M, Plata-Gomez A, Aureli S, Quezada Meza C, et al.
Sci Adv
. 2022 Aug;
8(35):eabo1215.
PMID: 36044577
Selective degradation of the endoplasmic reticulum (ER) via autophagy (ER-phagy) is initiated by ER-phagy receptors, which facilitate the incorporation of ER fragments into autophagosomes. FAM134 reticulon family proteins (FAM134A, FAM134B,...
12.
Santana F, Perfetti M, Briganti M, Sacco F, Poneti G, Ravera E, et al.
Chem Sci
. 2022 Jun;
13(20):5860-5871.
PMID: 35685802
A common criterion for designing performant single molecule magnets and pseudocontact shift tags is a large magnetic anisotropy. In this article we present a dysprosium complex chemically designed to exhibit...
13.
Rizzo D, Cerofolini L, Giuntini S, Iozzino L, Pergola C, Sacco F, et al.
J Am Chem Soc
. 2022 May;
144(22):10006-10016.
PMID: 35617699
Multispecific biologics are an emerging class of drugs, in which antibodies and/or proteins designed to bind pharmacological targets are covalently linked or expressed as fusion proteins to increase both therapeutic...
14.
Caliskan O, Massacci G, Krahmer N, Sacco F
Methods Mol Biol
. 2022 May;
2456:123-140.
PMID: 35612739
Over the recent years, mass spectrometry (MS)-based proteomics has undergone dramatic advances in sample preparation, instrumentation, and computational methods. Here, we describe in detail, how a workflow quantifies global protein...
15.
Ostaszewski M, Niarakis A, Mazein A, Kuperstein I, Phair R, Orta-Resendiz A, et al.
Mol Syst Biol
. 2021 Dec;
17(12):e10851.
PMID: 34939300
No abstract available.
16.
Ostaszewski M, Niarakis A, Mazein A, Kuperstein I, Phair R, Orta-Resendiz A, et al.
Mol Syst Biol
. 2021 Oct;
17(10):e10387.
PMID: 34664389
We need to effectively combine the knowledge from surging literature with complex datasets to propose mechanistic models of SARS-CoV-2 infection, improving data interpretation and predicting key targets of intervention. Here,...
17.
Sacco F, Tarchi M, Ferraro G, Merlino A, Facchetti G, Rimoldi I, et al.
Int J Mol Sci
. 2021 Oct;
22(19).
PMID: 34638887
Three novel platinum(II) complexes bearing N-heterocyclic ligands, i.e., Pt2c, Pt-IV and Pt-VIII, were previously prepared and characterized. They manifested promising in vitro anticancer properties associated with non-conventional modes of action....
18.
Cesareni G, Sacco F, Perfetto L
Front Genet
. 2021 Jun;
12:694468.
PMID: 34178043
The development of high-throughput high-content technologies and the increased ease in their application in clinical settings has raised the expectation of an important impact of these technologies on diagnosis and...
19.
Pugliese G, Latini S, Massacci G, Perfetto L, Sacco F
Proteomes
. 2021 Apr;
9(2).
PMID: 33925552
FLT3 mutations are the most frequently identified genetic alterations in acute myeloid leukemia (AML) and are associated with poor clinical outcome, relapse and chemotherapeutic resistance. Elucidating the molecular mechanisms underlying...
20.
Perfetto L, Micarelli E, Iannuccelli M, Lo Surdo P, Giuliani G, Latini S, et al.
Genes (Basel)
. 2021 Apr;
12(3).
PMID: 33809949
The coronavirus disease 2019 (COVID-19) pandemic has caused more than 2.3 million casualties worldwide and the lack of effective treatments is a major health concern. The development of targeted drugs...