Frances C Shaffo
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Explore the profile of Frances C Shaffo including associated specialties, affiliations and a list of published articles.
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5
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78
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Recent Articles
1.
Chen X, Dong T, Hu Y, Shaffo F, Belur N, Mazzulli J, et al.
J Clin Invest
. 2022 Jan;
132(5).
PMID: 35025759
Neuronal ceroid lipofuscinosis type 7 (CLN7) disease is a lysosomal storage disease caused by mutations in the facilitator superfamily domain containing 8 (MFSD8) gene, which encodes a membrane-bound lysosomal protein,...
2.
Goodspeed K, Perez-Palma E, Iqbal S, Cooper D, Scimemi A, Johannesen K, et al.
Brain Commun
. 2020 Nov;
2(2):fcaa170.
PMID: 33241211
Advances in gene discovery have identified genetic variants in the solute carrier family 6 member 1 gene as a monogenic cause of neurodevelopmental disorders, including epilepsy with myoclonic atonic seizures,...
3.
Shaffo F, Grodzki A, Fryer A, Lein P
Am J Physiol Lung Cell Mol Physiol
. 2018 Jun;
315(4):L485-L501.
PMID: 29952220
Numerous epidemiologic studies have identified an association between occupational exposures to organophosphorus pesticides (OPs) and asthma or asthmatic symptoms in adults. Emerging epidemiologic data suggest that environmentally relevant levels of...
4.
Shaffo F, Grodzki A, Schelegle E, Lein P
Toxicol Sci
. 2018 Jun;
165(1):244-253.
PMID: 29939342
Occupational and environmental exposures to organophosphorus pesticides (OPs) are associated with increased incidence of asthma and other pulmonary diseases. Although the canonical mechanism of OP neurotoxicity is inhibition of acetylcholinesterase...
5.
Courter L, Shaffo F, Ghogha A, Parrish D, Lorentz C, Habecker B, et al.
Dev Neurobiol
. 2015 Dec;
76(9):1003-13.
PMID: 26663679
Dendritic morphology is a critical determinant of neuronal connectivity, and in postganglionic sympathetic neurons, tonic activity correlates directly with the size of the dendritic arbor. Thus, identifying signaling mechanisms that...