Allison D Fryer
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Explore the profile of Allison D Fryer including associated specialties, affiliations and a list of published articles.
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74
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1545
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Recent Articles
1.
Williams K, Bright H, Fryer A, Jacoby D, Nie Z
JCI Insight
. 2025 Jan;
10(1.
PMID: 39782687
The impact of diet-induced maternal obesity on offspring airway hyperresponsiveness was studied in a diversity outbred mouse model that mirrors human genetic diversity. Female mice were started on high-fat or...
2.
Pincus A, Pierce A, Kappel N, Lebold K, Drake M, Fryer A, et al.
Am J Respir Cell Mol Biol
. 2024 Dec;
PMID: 39626221
Airway hyperreactivity in asthma is mediated by airway nerves, including sensory nerves in airway epithelium and parasympathetic nerves innervating airway smooth muscle. Isolating the function of these two nerve populations...
3.
Proskocil B, Bash G, Jacoby D, Fryer A, Nie Z
Am J Physiol Lung Cell Mol Physiol
. 2024 Sep;
327(6):L867-L875.
PMID: 39316677
Eosinophils contribute to metabolic homeostasis and airway hyperresponsiveness, but their specific role in obesity-related airway hyperresponsiveness remains unclear. To address this, we used transgenic mice that overexpress interleukin-5 (IL-5) in...
4.
Lebold K, Cook M, Pincus A, Nevonen K, Davis B, Carbone L, et al.
Am J Physiol Lung Cell Mol Physiol
. 2023 Oct;
325(6):L776-L787.
PMID: 37814791
Asthma susceptibility is influenced by environmental, genetic, and epigenetic factors. DNA methylation is one form of epigenetic modification that regulates gene expression and is both inherited and modified by environmental...
5.
Calco G, Alharithi Y, Williams K, Jacoby D, Fryer A, Maloyan A, et al.
Am J Physiol Lung Cell Mol Physiol
. 2023 Jun;
325(1):L66-L73.
PMID: 37280517
Children born to obese mothers are prone to develop asthma and airway hyperresponsiveness, but the mechanisms behind this are unclear. Here we developed a mouse model of maternal diet-induced obesity...
6.
Calco G, Maung J, Jacoby D, Fryer A, Nie Z
JCI Insight
. 2022 Sep;
7(20).
PMID: 36107629
Obesity-induced asthma responds poorly to all current pharmacological interventions, including steroids, suggesting that classic, eosinophilic inflammation is not a mechanism. Since insulin resistance and hyperinsulinemia are common in obese individuals...
7.
Nie Z, Fryer A, Jacoby D, Drake M
Am J Respir Crit Care Med
. 2022 Aug;
207(1):109-110.
PMID: 36029301
No abstract available.
8.
Lebold K, Drake M, Pincus A, Pierce A, Fryer A, Jacoby D
Am J Respir Cell Mol Biol
. 2022 Apr;
67(1):89-98.
PMID: 35363997
Asthma is a heterogeneous inflammatory airway disease that develops in response to a combination of genetic predisposition and environmental exposures. Patients with asthma are grouped into phenotypes with shared clinical...
9.
Pincus A, Huang S, Lebold K, De La Torre U, Proskocil B, Drake M, et al.
Sci Rep
. 2022 Mar;
12(1):5006.
PMID: 35322058
We report subpopulations of airway parasympathetic neurons expressing substance P, neuronal nitric oxide synthase, and tyrosine hydroxylase, highlighting unexplored heterogeneity in this population. These neurotransmitter-specific subpopulations did not form intraganglionic...
10.
Sadekar N, Boisleve F, Dekant W, Fryer A, Gerberick G, Griem P, et al.
Crit Rev Toxicol
. 2022 Feb;
51(10):792-804.
PMID: 35142253
The induction of immunological responses that trigger bio-physiological symptoms in the respiratory tract following repeated exposure to a substance, is known as respiratory sensitization. The inducing compound is known as...