Frances A Edwards
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Explore the profile of Frances A Edwards including associated specialties, affiliations and a list of published articles.
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27
Citations
895
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Recent Articles
1.
Wood J, Wood J, Dulewicz M, Ge J, Stringer K, Szadziewska A, et al.
Res Sq
. 2025 Feb;
PMID: 39975899
Understanding how amyloid beta (Aβ) plaques form and progress to neurotoxicity in Alzheimer's disease remains a significant challenge. This study aims to elucidate the processes involved in Aβ plaque formation...
2.
Desai S, Camporesi E, Brinkmalm G, Alatza A, Wood J, Tripathi T, et al.
bioRxiv
. 2024 Nov;
PMID: 39574656
Introducing heterozygous humanized tau to App knock-in mice results in the first mouse model of Alzheimer's disease in which age and amyloid-β pathology interact to initiate neurofibrillary tau tangle pathology,...
3.
Wood J, Dulewicz M, Ge J, Stringer K, Szadziewska A, Desai S, et al.
bioRxiv
. 2024 Oct;
PMID: 39416086
It is of critical importance to our understanding of Alzheimer's disease (AD) pathology to determine how key pathological factors are interconnected and implicated in nerve cell death, clinical symptoms, and...
4.
Wood J, Wong E, Joghee R, Balbaa A, Vitanova K, Stringer K, et al.
Cell Rep
. 2022 Nov;
41(8):111686.
PMID: 36417868
Using spatial cell-type-enriched transcriptomics, we compare plaque-induced gene (PIG) expression in microglia-touching plaques, neighboring plaques, and far from plaques in an aged Alzheimer's mouse model with late plaque development. In...
5.
Benitez D, Jiang S, Wood J, Wang R, Hall C, Peerboom C, et al.
Mol Neurodegener
. 2021 Jul;
16(1):47.
PMID: 34266459
Background: Microglia are active modulators of Alzheimer's disease but their role in relation to amyloid plaques and synaptic changes due to rising amyloid beta is unclear. We add novel findings...
6.
Michno W, Stringer K, Enzlein T, Passarelli M, Escrig S, Vitanova K, et al.
Sci Adv
. 2021 Jun;
7(25).
PMID: 34134980
β-Amyloid (Aβ) plaque formation is the major pathological hallmark of Alzheimer's disease (AD) and constitutes a potentially critical, early inducer driving AD pathogenesis as it precedes other pathological events and...
7.
Chaney A, Lopez-Picon F, Serriere S, Wang R, Bochicchio D, Webb S, et al.
Theranostics
. 2021 Jun;
11(14):6644-6667.
PMID: 34093845
Mouse models of Alzheimer's disease (AD) are valuable but do not fully recapitulate human AD pathology, such as spontaneous Tau fibril accumulation and neuronal loss, necessitating the development of new...
8.
Liu W, Taso O, Wang R, Bayram S, Graham A, Garcia-Reitboeck P, et al.
Hum Mol Genet
. 2020 Sep;
29(19):3224-3248.
PMID: 32959884
Genome-wide association studies have reported that, amongst other microglial genes, variants in TREM2 can profoundly increase the incidence of developing Alzheimer's disease (AD). We have investigated the role of TREM2...
9.
Hardy J, Hernandez D, Cummings D, Edwards F, Shear J, Schmidt C
J Mater Chem B
. 2020 Apr;
3(25):5001-5004.
PMID: 32262453
We report the application of multiphoton microfabrication to prepare conducting polymer (CP)-based biomaterials that were capable of drug delivery and interacting with brain tissue ex vivo, thereby highlighting the potential...
10.
Guarascio R, Salih D, Yasvoina M, Edwards F, Cheetham M, van der Spuy J
Hum Mol Genet
. 2019 Nov;
29(1):80-96.
PMID: 31691796
Negative regulator of ubiquitin-like protein 1 (NUB1) and its longer isoform NUB1L are ubiquitin-like (UBL)/ubiquitin-associated (UBA) proteins that facilitate the targeting of proteasomal substrates, including tau, synphilin-1 and huntingtin. Previous...