Aaron W Feldman
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Explore the profile of Aaron W Feldman including associated specialties, affiliations and a list of published articles.
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14
Citations
365
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Recent Articles
1.
Oh J, Shin J, Unarta I, Wang W, Feldman A, Karadeema R, et al.
Nat Chem Biol
. 2021 Jun;
17(8):906-914.
PMID: 34140682
The development of unnatural base pairs (UBPs) has greatly increased the information storage capacity of DNA, allowing for transcription of unnatural RNA by the heterologously expressed T7 RNA polymerase (RNAP)...
2.
Fischer E, Hashimoto K, Zhang Y, Feldman A, Dien V, Karadeema R, et al.
Nat Chem Biol
. 2020 Apr;
16(5):570-576.
PMID: 32251411
Natural organisms use a four-letter genetic alphabet that makes available 64 triplet codons, of which 61 are sense codons used to encode proteins with the 20 canonical amino acids. We...
3.
Zhou A, Sheng K, Feldman A, Romesberg F
J Am Chem Soc
. 2019 Dec;
141(51):20166-20170.
PMID: 31841336
We have created a bacterial semisynthetic organism (SSO) that retains an unnatural base pair (UBP) in its DNA, transcribes it into mRNA and tRNA with cognate unnatural codons and anticodons,...
4.
Feldman A, Dien V, Karadeema R, Fischer E, You Y, Anderson B, et al.
J Am Chem Soc
. 2019 Jun;
141(27):10644-10653.
PMID: 31241334
Previously, we reported the creation of a semi-synthetic organism (SSO) that stores and retrieves increased information by virtue of stably maintaining an unnatural base pair (UBP) in its DNA, transcribing...
5.
Dien V, Holcomb M, Feldman A, Fischer E, Dwyer T, Romesberg F
J Am Chem Soc
. 2018 Nov;
140(47):16115-16123.
PMID: 30418780
We have developed a family of unnatural base pairs (UBPs), exemplified by the pair formed between dNaM and dTPT3, for which pairing is mediated not by complementary hydrogen bonding but...
6.
Feldman A, Fischer E, Ledbetter M, Liao J, Chaput J, Romesberg F
J Am Chem Soc
. 2018 Jan;
140(4):1447-1454.
PMID: 29338214
Nucleoside triphosphates play a central role in biology, but efforts to study these roles have proven difficult because the levels of triphosphates are tightly regulated in a cell and because...
7.
Feldman A, Romesberg F
Acc Chem Res
. 2017 Dec;
51(2):394-403.
PMID: 29198111
The information available to any organism is encoded in a four nucleotide, two base pair genetic code. Since its earliest days, the field of synthetic biology has endeavored to impart...
8.
Zhang Y, Ptacin J, Fischer E, Aerni H, Caffaro C, San Jose K, et al.
Nature
. 2017 Dec;
551(7682):644-647.
PMID: 29189780
Since at least the last common ancestor of all life on Earth, genetic information has been stored in a four-letter alphabet that is propagated and retrieved by the formation of...
9.
Feldman A, Romesberg F
J Am Chem Soc
. 2017 Aug;
139(33):11427-11433.
PMID: 28796508
In an effort to expand the genetic alphabet and create semi-synthetic organisms (SSOs) that store and retrieve increased information, we have developed the unnatural base pairs (UBPs) dNaM and d5SICS...
10.
Feldman A, Ledbetter M, Zhang Y, Romesberg F
Proc Natl Acad Sci U S A
. 2017 Aug;
114(32):E6478-E6479.
PMID: 28768812
No abstract available.