Florian Wilfling
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Explore the profile of Florian Wilfling including associated specialties, affiliations and a list of published articles.
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34
Citations
1510
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Recent Articles
1.
Licheva M, Babic R, Pflaum J, Mancilla H, Wilfling F, Kraft C
Autophagy
. 2025 Mar;
:1-3.
PMID: 40052694
Selective macroautophagy/autophagy relies on newly formed double-membrane compartments, known as phagophores, to sequester and recycle diverse cellular components, including organelles, biomolecular condensates and protein aggregates, maturing into autophagosomes that fuse...
2.
Kraus F, He Y, Swarup S, Overmyer K, Jiang Y, Brenner J, et al.
Sci Adv
. 2025 Jan;
11(4):eadu5787.
PMID: 39841834
Lysosomal storage diseases (LSDs) comprise ~50 monogenic disorders marked by the buildup of cellular material in lysosomes, yet systematic global molecular phenotyping of proteins and lipids is lacking. We present...
3.
Licheva M, Pflaum J, Babic R, Mancilla H, Elsasser J, Boyle E, et al.
Nat Cell Biol
. 2025 Jan;
27(2):283-297.
PMID: 39774270
Autophagy is a key cellular quality control mechanism. Nutrient stress triggers bulk autophagy, which nonselectively degrades cytoplasmic material upon formation and liquid-liquid phase separation of the autophagy-related gene 1 (Atg1)...
4.
Grizel A, Gorsheneva N, Stevenson J, Pflaum J, Wilfling F, Rubel A, et al.
J Biol Chem
. 2024 Sep;
300(10):107766.
PMID: 39276934
Liquid protein condensates produced by phase separation are involved in the spatiotemporal control of cellular functions, while solid fibrous aggregates (amyloids) are associated with diseases and/or manifest as infectious or...
5.
6.
Zhao D, Bauerlein F, Saha I, Hartl F, Baumeister W, Wilfling F
Mol Cell
. 2024 May;
84(10):1980-1994.e8.
PMID: 38759629
Aggregation of proteins containing expanded polyglutamine (polyQ) repeats is the cytopathologic hallmark of a group of dominantly inherited neurodegenerative diseases, including Huntington's disease (HD). Huntingtin (Htt), the disease protein of...
7.
Lizarrondo J, Wilfling F
J Mol Biol
. 2024 Apr;
436(15):168574.
PMID: 38636617
Proteins are known to perform an astonishing array of functions thanks to their ability to cooperate and modulate each other's properties. Inside cells, proteins can assemble into large multi-subunit complexes...
8.
Kraus F, He Y, Swarup S, Overmyer K, Jiang Y, Brenner J, et al.
bioRxiv
. 2024 Apr;
PMID: 38585873
Lysosomal storage diseases (LSDs) comprise ~50 monogenic disorders marked by the buildup of cellular material in lysosomes, yet systematic global molecular phenotyping of proteins and lipids is lacking. We present...
9.
Hoyer M, Capitanio C, Smith I, Paoli J, Bieber A, Jiang Y, et al.
Nat Cell Biol
. 2024 Mar;
26(3):378-392.
PMID: 38429475
The endoplasmic reticulum (ER) employs a diverse proteome landscape to orchestrate many cellular functions, ranging from protein and lipid synthesis to calcium ion flux and inter-organelle communication. A case in...
10.
Wilfling F, Kaksonen M, Stachowiak J
Curr Opin Cell Biol
. 2023 Oct;
85:102258.
PMID: 37832166
With an essential role in nearly every physiological process and disease state, trafficking vesicles are fundamental to cell biology. Canonical understanding of membrane traffic has been driven by key achievements...