Florian Wilfling
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Explore the profile of Florian Wilfling including associated specialties, affiliations and a list of published articles.
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34
Citations
1510
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Recent Articles
11.
Boyle E, Wilfling F
FEBS Lett
. 2023 Aug;
597(22):2728-2738.
PMID: 37567863
Due to their essential functions, dysregulation of nuclear pore complexes (NPCs) is strongly associated with numerous human diseases, including neurodegeneration and cancer. On a cellular level, longevity of scaffold nucleoporins...
12.
Hoyer M, Capitanio C, Smith I, Paoli J, Bieber A, Jiang Y, et al.
bioRxiv
. 2023 Jul;
PMID: 37425907
The endoplasmic reticulum (ER) employs a diverse proteome landscape to orchestrate many cellular functions ranging from protein and lipid synthesis to calcium ion flux and inter-organelle communication. A case in...
13.
Capitanio C, Bieber A, Wilfling F
Contact (Thousand Oaks)
. 2023 Jun;
6:25152564231162495.
PMID: 37366413
During macroautophagy, phagophores establish multiple membrane contact sites (MCSs) with other organelles that are pivotal for proper phagophore assembly and growth. In , phagophore contacts have been observed with the...
14.
Li M, Tripathi-Giesgen I, Schulman B, Baumeister W, Wilfling F
Proc Natl Acad Sci U S A
. 2023 Mar;
120(12):e2221712120.
PMID: 36917659
Selective macroautophagy (hereafter referred to as autophagy) describes a process in which cytosolic material is engulfed in a double membrane organelle called an autophagosome. Autophagosomes are carriers responsible for delivering...
15.
Schmitt D, Bozkurt S, Henning-Domres P, Huesmann H, Eimer S, Bindila L, et al.
Autophagy
. 2022 Nov;
19(7):2146-2147.
PMID: 36416088
Autophagosome isolation enables the thorough investigation of structural components and engulfed materials. Recently, we introduced a novel antibody-based FACS-mediated method for isolation of native macroautophagic/autophagic vesicles and confirmed the quality...
16.
Schmitt D, Bozkurt S, Henning-Domres P, Huesmann H, Eimer S, Bindila L, et al.
EMBO Rep
. 2022 Oct;
23(12):e53065.
PMID: 36215690
Autophagy is responsible for clearance of an extensive portfolio of cargoes, which are sequestered into vesicles, called autophagosomes, and are delivered to lysosomes for degradation. The pathway is highly dynamic...
17.
Bieber A, Capitanio C, Erdmann P, Fiedler F, Beck F, Lee C, et al.
Proc Natl Acad Sci U S A
. 2022 Sep;
119(39):e2209823119.
PMID: 36122245
Autophagosomes are unique organelles that form de novo as double-membrane vesicles engulfing cytosolic material for destruction. Their biogenesis involves membrane transformations of distinctly shaped intermediates whose ultrastructure is poorly understood....
18.
Qiao S, Lee C, Sherpa D, Chrustowicz J, Cheng J, Duennebacke M, et al.
Nat Commun
. 2022 Jun;
13(1):3041.
PMID: 35650207
Protein degradation, a major eukaryotic response to cellular signals, is subject to numerous layers of regulation. In yeast, the evolutionarily conserved GID E3 ligase mediates glucose-induced degradation of fructose-1,6-bisphosphatase (Fbp1),...
19.
Enenkel C, Kang R, Wilfling F, Ernst O
J Biol Chem
. 2022 May;
298(7):102083.
PMID: 35636514
The ubiquitin-proteasome system fulfills an essential role in regulating protein homeostasis by spatially and temporally controlling proteolysis in an ATP- and ubiquitin-dependent manner. However, the localization of proteasomes is highly...
20.
Boyle E, Wilfling F
Mol Cell
. 2022 Mar;
82(5):886-888.
PMID: 35245454
Zervopoulos et al. (2022) propose a non-canonical nuclear import pathway for the functional mitochondrial pyruvate dehydrogenase complex (PDC), facilitated by dynamic MFN2-mediated tethering of mitochondria to the nuclear envelope upon...