Florian Settele
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Explore the profile of Florian Settele including associated specialties, affiliations and a list of published articles.
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10
Citations
330
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Recent Articles
1.
Katzschmann A, Haupts U, Reimann A, Settele F, Gloser-Braunig M, Fiedler E, et al.
Commun Biol
. 2024 Jul;
7(1):907.
PMID: 39068227
Affilin proteins, artificial binding proteins based on the ubiquitin scaffold, have been generated by directed protein evolution to yield de-novo variants that bind the extra-domain B (EDB) of oncofetal fibronectin,...
2.
Kahl M, Settele F, Knick P, Haupts U, Bosse-Doenecke E
Protein Expr Purif
. 2018 Apr;
149:51-65.
PMID: 29704557
Protein based binding molecules have a broad applicability from therapeutic to technical use. Monoclonal antibodies represent the major class of this type of agents complemented by innovative approaches using scaffold...
3.
Settele F, Zwarg M, Fiedler S, Koscheinz D, Bosse-Doenecke E
Methods Mol Biol
. 2017 Nov;
1701:205-238.
PMID: 29116507
Affilin molecules represent a new class of so-called scaffold proteins. The concept of scaffold proteins is to use stable and versatile protein structures which can be endowed with de novo...
4.
Job F, Settele F, Lorey S, Rundfeldt C, Baumann L, Beck-Sickinger A, et al.
FEBS Open Bio
. 2015 Aug;
5:579-93.
PMID: 26258013
In the search for effective therapeutic strategies, protein-based biologicals are under intense development. While monoclonal antibodies represent the majority of these drugs, other innovative approaches are exploring the use of...
5.
Zhu M, Settele F, Kotak S, Sanchez-Pulido L, Ehret L, Ponting C, et al.
J Cell Biol
. 2013 Mar;
200(6):773-87.
PMID: 23509069
Precise positioning of the mitotic spindle determines the correct cell division axis and is crucial for organism development. Spindle positioning is mediated through a cortical machinery by capturing astral microtubules,...
6.
Cizmecioglu O, Arnold M, Bahtz R, Settele F, Ehret L, Haselmann-Weiss U, et al.
J Cell Biol
. 2010 Nov;
191(4):731-9.
PMID: 21059844
Both gain and loss of function studies have identified the Polo-like kinase Plk4/Sak as a crucial regulator of centriole biogenesis, but the mechanisms governing centrosome duplication are incompletely understood. In...
7.
Timofeev O, Cizmecioglu O, Settele F, Kempf T, Hoffmann I
J Biol Chem
. 2010 Apr;
285(22):16978-90.
PMID: 20360007
Progression through mitosis requires the coordinated regulation of Cdk1 kinase activity. Activation of Cdk1 is a multistep process comprising binding of Cdk1 to cyclin B, relocation of cyclin-kinase complexes to...
8.
Barth E, Gora K, Gebendorfer K, Settele F, Jakob U, Winter J
Microbiology (Reading)
. 2009 Apr;
155(Pt 5):1680-1689.
PMID: 19372151
Hypochlorous acid (HOCl), the active ingredient of household bleach, functions as a powerful antimicrobial that is used not only in numerous industrial applications but also in mammalian host defence. Here...
9.
Spath B, Schubert S, Lieberoth A, Settele F, Schutz S, Fischer S, et al.
Arch Microbiol
. 2008 Apr;
190(3):301-8.
PMID: 18437358
The endoribonuclease tRNase Z plays an essential role in tRNA metabolism by removal of the 3' trailer element of precursor RNAs. To investigate tRNA processing in archaea, we identified and...
10.
Spath B, Settele F, Schilling O, DAngelo I, Vogel A, Feldmann I, et al.
Biochemistry
. 2007 Dec;
46(51):14742-50.
PMID: 18052196
The endonuclease tRNase Z from A. thaliana (AthTRZ1) was originally isolated for its tRNA 3' processing activity. Here we show that AthTRZ1 also hydrolyzes the phosphodiester bond in bis(p-nitrophenyl) phosphate...