Alpha 2.0
Login Register
» Authors » Florian Opperer

Florian Opperer

Explore the profile of Florian Opperer including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 6
Citations 113
Followers 0
Related Specialties
Biology
Chemistry
General Medicine
Top 10 Co-Authors
Horst Kessler
Victor J Hruby
Johannes G Beck
Minying Cai
Lucas Doedens
Udaya Kiran Marelli
Chaim Gilon
Florian Rechenmacher
Jayanta Chatterjee
Philipp Angerer
Published In
Adv Exp Med Biol
J Med Chem
J Am Chem Soc
Biochemistry
Mol Pharm
Affiliations
Soon will be listed here.
Recent Articles
1.
BART-Seq: cost-effective massively parallelized targeted sequencing for genomics, transcriptomics, and single-cell analysis
Uzbas F, Opperer F, Sonmezer C, Shaposhnikov D, Sass S, Krendl C, et al.
Genome Biol . 2019 Aug; 20(1):155. PMID: 31387612
We describe a highly sensitive, quantitative, and inexpensive technique for targeted sequencing of transcript cohorts or genomic regions from thousands of bulk samples or single cells in parallel. Multiplexing is...
2.
Structural Insights into Selective Ligand-Receptor Interactions Leading to Receptor Inactivation Utilizing Selective Melanocortin 3 Receptor Antagonists
Cai M, Kiran Marelli U, Mertz B, Beck J, Opperer F, Rechenmacher F, et al.
Biochemistry . 2017 Jul; 56(32):4201-4209. PMID: 28715181
Systematic N-methylated derivatives of the melanocortin receptor ligand, SHU9119, lead to multiple binding and functional selectivity toward melanocortin receptors. However, the relationship between N-methylation-induced conformational changes in the peptide backbone...
3.
Systematic Backbone Conformational Constraints on a Cyclic Melanotropin Ligand Leads to Highly Selective Ligands for Multiple Melanocortin Receptors
Cai M, Kiran Marelli U, Bao J, Beck J, Opperer F, Rechenmacher F, et al.
J Med Chem . 2015 Jul; 58(16):6359-67. PMID: 26218460
Human melanocortin receptors (hMCRs) have been challenging targets to develop ligands that are explicitly selective for each of their subtypes. To modulate the conformational preferences of the melanocortin ligands and...
4.
The effect of multiple N-methylation on intestinal permeability of cyclic hexapeptides
Ovadia O, Greenberg S, Chatterjee J, Laufer B, Opperer F, Kessler H, et al.
Mol Pharm . 2011 Mar; 8(2):479-87. PMID: 21375270
Recent progress in peptide synthesis simplified the synthesis of multiple N-methylation of peptides. To evaluate how multiple N-methylation affects the bioavailability of peptides, a poly alanine cyclic hexapeptide library (n...
5.
Multiple N-methylation of MT-II backbone amide bonds leads to melanocortin receptor subtype hMC1R selectivity: pharmacological and conformational studies
Doedens L, Opperer F, Cai M, Beck J, Dedek M, Palmer E, et al.
J Am Chem Soc . 2010 May; 132(23):8115-28. PMID: 20496895
Multiple N-methylation is a novel technology to improve bioavailability of peptides and increase receptor subtype selectivity. This technique has been applied here to the superpotent but nonselective cyclic peptide MT-II....
6.
New perspective in peptide chemistry by N-alkylation
Kessler H, Chatterjee J, Doedens L, Opperer F, Biron E, Hoyer D, et al.
Adv Exp Med Biol . 2009 Apr; 611:229-31. PMID: 19400173
No abstract available.