Florian Heigwer
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Explore the profile of Florian Heigwer including associated specialties, affiliations and a list of published articles.
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23
Citations
1405
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Recent Articles
1.
Hofman T, Ng S, Garces-Lazaro I, Heigwer F, Boutros M, Cerwenka A
J Immunother Cancer
. 2024 Jul;
12(7).
PMID: 38955423
Background: Immune checkpoint blockade targeting the adaptive immune system has revolutionized the treatment of cancer. Despite impressive clinical benefits observed, patient subgroups remain non-responsive underscoring the necessity for combinational therapies...
2.
Funk M, Gleixner J, Heigwer F, Vonficht D, Valentini E, Aydin Z, et al.
Dev Cell
. 2023 Dec;
58(24):2914-2929.e7.
PMID: 38113852
Low-grade chronic inflammation is a hallmark of ageing, associated with impaired tissue function and disease development. However, how cell-intrinsic and -extrinsic factors collectively establish this phenotype, termed inflammaging, remains poorly...
3.
Prasad V, Cerikan B, Stahl Y, Kopp K, Magg V, Acosta-Rivero N, et al.
Mol Cell
. 2023 Jul;
83(14):2559-2577.e8.
PMID: 37421942
Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) remodels the endoplasmic reticulum (ER) to form replication organelles, leading to ER stress and unfolded protein response (UPR). However, the role of specific UPR...
4.
Heigwer F, Scheeder C, Bageritz J, Yousefian S, Rauscher B, Laufer C, et al.
Cell Syst
. 2023 Apr;
14(5):346-362.e6.
PMID: 37116498
Cellular and organismal phenotypes are controlled by complex gene regulatory networks. However, reference maps of gene function are still scarce across different organisms. Here, we generated synthetic genetic interaction and...
5.
Bamberg L, Heigwer F, Wandmacher A, Singh A, Betge J, Rindtorff N, et al.
Int J Cancer
. 2022 Jun;
151(9):1586-1601.
PMID: 35666536
Epigenetic dysregulation is an important feature of colorectal cancer (CRC). Combining epigenetic drugs with other antineoplastic agents is a promising treatment strategy for advanced cancers. Here, we exploited the concept...
6.
Neufeldt C, Cerikan B, Cortese M, Frankish J, Lee J, Plociennikowska A, et al.
Commun Biol
. 2022 Jan;
5(1):45.
PMID: 35022513
SARS-CoV-2 is a novel virus that has rapidly spread, causing a global pandemic. In the majority of infected patients, SARS-CoV-2 leads to mild disease; however, in a significant proportion of...
7.
Heigwer F, Boutros M
Methods Mol Biol
. 2020 Sep;
2162:3-22.
PMID: 32926374
CRISPR/Cas-based genome editing in any biological application requires the evaluation of suitable genomic target sites to design efficient reagents. Considerations for the design of short guide (sg) RNAs include the...
8.
Port F, Strein C, Stricker M, Rauscher B, Heigwer F, Zhou J, et al.
Elife
. 2020 Feb;
9.
PMID: 32053108
Genetic screens are powerful tools for the functional annotation of genomes. In the context of multicellular organisms, interrogation of gene function is greatly facilitated by methods that allow spatial and...
9.
Heigwer F, Scheeder C, Miersch T, Schmitt B, Blass C, Pour Jamnani M, et al.
Elife
. 2018 Dec;
7.
PMID: 30592458
Editorial Note: This article has been through an editorial process in which the authors decide how to respond to the issues raised during peer review. The Reviewing Editor's assessment is...
10.
Scheeder C, Heigwer F, Boutros M
Curr Opin Syst Biol
. 2018 Aug;
10:43-52.
PMID: 30159406
The increase in imaging throughput, new analytical frameworks and high-performance computational resources open new avenues for data-rich phenotypic profiling of small molecules in drug discovery. Image-based profiling assays assessing single-cell...