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Flonia Levy-Adam

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Articles 22
Citations 881
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Recent Articles
1.
Akaree N, Secco V, Levy-Adam F, Younis A, Carra S, Shalgi R
FEBS J . 2025 Jan; PMID: 39756021
Biomolecular condensates are dynamic membraneless compartments that regulate a myriad of cellular functions. A particular type of physiological condensate called stress granules (SGs) has gained increasing interest due to its...
2.
Sabath N, Levy-Adam F, Younis A, Rozales K, Meller A, Hadar S, et al.
Proc Natl Acad Sci U S A . 2020 Dec; 117(50):31902-31913. PMID: 33257563
Proteostasis collapse, the diminished ability to maintain protein homeostasis, has been established as a hallmark of nematode aging. However, whether proteostasis collapse occurs in humans has remained unclear. Here, we...
3.
Hakim-Mishnaevski K, Flint-Brodsly N, Shklyar B, Levy-Adam F, Kurant E
Cell Rep . 2019 Nov; 29(6):1438-1448.e3. PMID: 31693886
Glial phagocytosis is critical for the development and maintenance of the CNS in vertebrates and flies and relies on the function of phagocytic receptors to remove apoptotic cells and debris....
4.
Shlyakhover E, Shklyar B, Hakim-Mishnaevski K, Levy-Adam F, Kurant E
Front Immunol . 2018 Mar; 9:266. PMID: 29568295
During embryogenesis, a large number of apoptotic cells are efficiently engulfed and degraded by professional phagocytes, macrophages. Phagocytic receptors Six-Microns-Under (SIMU), Draper (Drpr) and Croquemort (Crq) are specifically expressed in...
5.
Hilu-Dadia R, Hakim-Mishnaevski K, Levy-Adam F, Kurant E
Glia . 2018 Mar; 66(7):1520-1532. PMID: 29520845
Development of the central nervous system involves elimination of superfluous neurons through apoptosis and subsequent phagocytosis. In Drosophila, this occurs mainly during three developmental stages: embryogenesis, metamorphosis and emerging adult....
6.
Vilborg A, Sabath N, Wiesel Y, Nathans J, Levy-Adam F, Yario T, et al.
Proc Natl Acad Sci U S A . 2017 Sep; 114(40):E8362-E8371. PMID: 28928151
Transcription is a highly regulated process, and stress-induced changes in gene transcription have been shown to play a major role in stress responses and adaptation. Genome-wide studies reveal prevalent transcription...
7.
Shklover J, Levy-Adam F, Kurant E
Curr Top Dev Biol . 2015 Oct; 114:297-334. PMID: 26431572
Programmed cell death and its specific form apoptosis play an important role during development of multicellular organisms. They are crucial for morphogenesis and organ sculpting as well as for adjusting...
8.
Shklover J, Levy-Adam F, Kurant E
FEBS Lett . 2015 Mar; 589(8):871-9. PMID: 25754009
Eiger, the sole Drosophila TNF-alpha homolog, causes ectopic apoptosis through JNK pathway activation. Yet, its role in developmental apoptosis remains unclear. eiger mutant flies are viable and fertile but display...
9.
Shklyar B, Levy-Adam F, Kurant E
Methods Mol Biol . 2014 Nov; 1254:359-68. PMID: 25431078
During central nervous system (CNS ) development, a large number of neurons die by apoptosis and are efficiently removed through phagocytosis. Since apoptosis and apoptotic cell clearance are highly conserved...
10.
Shklyar B, Sellman Y, Shklover J, Mishnaevski K, Levy-Adam F, Kurant E
Dev Biol . 2014 Jul; 393(2):255-269. PMID: 25046770
The proper removal of superfluous neurons through apoptosis and subsequent phagocytosis is essential for normal development of the central nervous system (CNS). During Drosophila embryogenesis, a large number of apoptotic...