Fengrong Xu
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Explore the profile of Fengrong Xu including associated specialties, affiliations and a list of published articles.
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25
Citations
89
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Recent Articles
1.
Wang C, Zheng C, Wang H, Shui S, Jin H, Liu G, et al.
Eur J Med Chem
. 2023 Jan;
247:115072.
PMID: 36603510
Targeting Glutathione peroxidase 4 (GPX4) has become a promising strategy for drug-resistant cancer therapy via ferroptosis induction. It was found that the GPX4 inhibitors such as RSL3 have GPX4 degradation...
2.
Lu Z, Li X, Li K, Ripani P, Shi X, Xu F, et al.
Biochem Pharmacol
. 2022 Jan;
197:114913.
PMID: 35032461
Nitazoxanide and related thiazolides are a novel class of anti-infectious agents against protozoan parasites, bacteria and viruses. In recent years, it is demonstrated that thiazolides can also induce cell cycle...
3.
Li X, Lu Z, Wang C, Li K, Xu F, Xu P, et al.
ACS Med Chem Lett
. 2021 May;
12(5):720-725.
PMID: 34055217
The abnormally high expression of glutathione transferases is closely associated with cancer incidence and drug resistance. By introducing a hydrophobic moiety to the inhibitor structure, we organized a series of...
4.
Lu Z, Li X, Li K, Wang C, Du T, Huang W, et al.
ACS Med Chem Lett
. 2021 May;
12(5):696-703.
PMID: 34055214
We identified nitazoxanide () as a moderate STAT3 pathway inhibitor through immunoblot analysis and a cell-based IL-6/JAK/STAT3 pathway activation assay. A series of thiazolide derivatives were designed and synthesized to...
5.
Wang C, Wang H, Zheng C, Liu Z, Gao X, Xu F, et al.
Eur J Med Chem
. 2021 Mar;
218:113386.
PMID: 33774345
Mitogen-activated protein kinase kinases 1 and 2 (MEK1/2) are the crucial part of the RAS-RAF-MEK-ERK pathway (or ERK pathway), which is involved in the regulation of various cellular processes including...
6.
Wang J, Zhu Y, Yang L, Liu H, Zhou T, Xu F, et al.
ACS Sens
. 2021 Mar;
6(3):1330-1338.
PMID: 33653024
In vivo imaging of cerebral hydrogen peroxide (H2O2) may facilitate early diagnosis of cerebral ischemia reperfusion injury (CIRI) and a revelation of its pathological progression. In this study, we report...
7.
Wang C, Xi D, Wang H, Niu Y, Liang L, Xu F, et al.
Eur J Med Chem
. 2020 Apr;
196:112271.
PMID: 32305784
A series of hybrids of MEK inhibitor and nitric oxide donor have been designed and synthesized. Compound 18h [4-(3-((3-(2-fluoro-3-((N-methylsulfamoyl)amino)benzyl)-4-methyl-2-oxo-2H-chromen-7-yl)oxy) propoxy)-3-(phenylsulfonyl)-1,2,5-oxadiazole 2-oxide] was proven to be more potent than the clinical...
8.
Sun Q, Zhou T, Xi D, Li X, Lu Z, Xu F, et al.
Eur J Med Chem
. 2020 Mar;
192:112160.
PMID: 32146375
A series of tripeptidic proteasome inhibitors with furylketone as C-terminus were designed and synthesized. Biochemical evaluations against β1, β2 and β5 subunits revealed that they acted selectively on β5 subunit...
9.
Zhou T, Wang J, Xu J, Zheng C, Niu Y, Wang C, et al.
Anal Chem
. 2020 Mar;
92(7):5064-5072.
PMID: 32122120
On the basis of the pyridazinone scaffold and photoinduced electron transfer (PET) mechanism, we designed a smart nitric oxide (NO) probe, , with high sensitivity and selectivity. exhibited a rapid...
10.
Xi D, Niu Y, Li H, Noha S, Temml V, Schuster D, et al.
Eur J Med Chem
. 2019 Jun;
178:802-817.
PMID: 31252285
We report in this work the discovery of novel allosteric MEK inhibitors by pharmacophore modeling and virtual screening. Two out of 13 virtual hit compounds were identified as MEK kinase...