Felix Randow
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Explore the profile of Felix Randow including associated specialties, affiliations and a list of published articles.
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51
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10356
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Recent Articles
11.
Canton J, Blees H, Henry C, Buck M, Schulz O, Rogers N, et al.
Nat Immunol
. 2020 Dec;
22(2):140-153.
PMID: 33349708
Type 1 conventional dendritic (cDC1) cells are necessary for cross-presentation of many viral and tumor antigens to CD8 T cells. cDC1 cells can be identified in mice and humans by...
12.
Ellison C, Kukulski W, Boyle K, Munro S, Randow F
Curr Biol
. 2020 Jul;
30(15):2974-2983.e6.
PMID: 32649908
Pathogenic bacteria enter the cytosol of host cells through uptake into bacteria-containing vacuoles (BCVs) and subsequent rupture of the vacuolar membrane [1]. Bacterial invaders are sensed either directly, through cytosolic...
13.
Wandel M, Kim B, Park E, Boyle K, Nayak K, Lagrange B, et al.
Nat Immunol
. 2020 Jun;
21(8):880-891.
PMID: 32541830
Bacterial lipopolysaccharide triggers human caspase-4 (murine caspase-11) to cleave gasdermin-D and induce pyroptotic cell death. How lipopolysaccharide sequestered in the membranes of cytosol-invading bacteria activates caspases remains unknown. Here we...
14.
Boyle K, Ravenhill B, Randow F
Autophagy
. 2019 Jul;
15(9):1655-1656.
PMID: 31258038
The selective macroautophagy of prospective cargo necessitates activity of the autophagy machinery at cargo-determined locations. Whether phagophore membranes are recruited to, or are generated at, the cargo is unknown. In...
15.
Ravenhill B, Boyle K, von Muhlinen N, Ellison C, Masson G, Otten E, et al.
Mol Cell
. 2019 Mar;
74(2):320-329.e6.
PMID: 30853402
Xenophagy, a selective autophagy pathway that protects the cytosol against bacterial invasion, relies on cargo receptors that juxtapose bacteria and phagophore membranes. Whether phagophores are recruited from a constitutive pool...
16.
Vargas J, Wang C, Bunker E, Hao L, Maric D, Schiavo G, et al.
Mol Cell
. 2019 Mar;
74(2):347-362.e6.
PMID: 30853401
Selective autophagy recycles damaged organelles and clears intracellular pathogens to prevent their aberrant accumulation. How ULK1 kinase is targeted and activated during selective autophagic events remains to be elucidated. In...
17.
Boyle K, Randow F
Methods Mol Biol
. 2019 Jan;
1880:679-690.
PMID: 30610731
Bacteria that escape from membrane-enclosed vacuoles to the cytosol of cells are targeted by autophagy, which recognizes and captures bacteria into autophagosomes wherein their proliferation is restricted. Here we discuss...
18.
Falcon B, Noad J, McMahon H, Randow F, Goedert M
J Biol Chem
. 2017 Dec;
293(7):2438-2451.
PMID: 29282296
Assembled tau can transfer between cells and seed the aggregation of soluble tau. This process is thought to underlie the amplification and propagation of tau inclusions throughout the brain in...
19.
Wandel M, Pathe C, Werner E, Ellison C, Boyle K, von der Malsburg A, et al.
Cell Host Microbe
. 2017 Oct;
22(4):507-518.e5.
PMID: 29024643
Interferon exposure boosts cell-autonomous immunity for more efficient pathogen control. But how interferon-enhanced immunity protects the cytosol against bacteria and how professionally cytosol-dwelling bacteria avoid clearance are insufficiently understood. Here...
20.
Noad J, von der Malsburg A, Pathe C, Michel M, Komander D, Randow F
Nat Microbiol
. 2017 May;
2:17063.
PMID: 28481331
Cell-autonomous immunity relies on the ubiquitin coat surrounding cytosol-invading bacteria functioning as an 'eat-me' signal for xenophagy. The origin, composition and precise mode of action of the ubiquitin coat remain...