Felix Randow
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Explore the profile of Felix Randow including associated specialties, affiliations and a list of published articles.
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51
Citations
10356
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Recent Articles
21.
Komander D, Randow F
Cell Host Microbe
. 2017 Feb;
21(2):127-129.
PMID: 28182945
Three recent papers, including one by Kotewicz et al. (2016) in this issue of Cell Host & Microbe, show that Legionella deploys a novel form of ubiquitylation to generate its...
22.
Boyle K, Thurston T, Randow F
Autophagy
. 2016 Nov;
12(12):2508-2509.
PMID: 27753515
Defense of the mammalian cell cytosol against Salmonella invasion is reliant upon capture of the infiltrating bacteria by macroautophagy (hereafter autophagy), a process controlled by the kinase TBK1. In our...
23.
Thurston T, Boyle K, Allen M, Ravenhill B, Karpiyevich M, Bloor S, et al.
EMBO J
. 2016 Jul;
35(16):1779-92.
PMID: 27370208
Mammalian cells deploy autophagy to defend their cytosol against bacterial invaders. Anti-bacterial autophagy relies on the core autophagy machinery, cargo receptors, and "eat-me" signals such as galectin-8 and ubiquitin that...
24.
Klionsky D, Abdelmohsen K, Abe A, Abedin M, Abeliovich H, Arozena A, et al.
Autophagy
. 2016 Jan;
12(1):1-222.
PMID: 26799652
No abstract available.
25.
Boyle K, Randow F
Nat Cell Biol
. 2015 Jul;
17(7):843-5.
PMID: 26123110
Phagocytic cells engulf their prey into vesicular structures called phagosomes, of which a certain proportion becomes demarcated for enhanced maturation by a process called LC3-associated phagocytosis (LAP). Light has now...
26.
Boname J, Bloor S, Wandel M, Nathan J, Antrobus R, Dingwell K, et al.
J Cell Biol
. 2014 Jun;
205(6):847-62.
PMID: 24958774
The regulated turnover of endoplasmic reticulum (ER)-resident membrane proteins requires their extraction from the membrane lipid bilayer and subsequent proteasome-mediated degradation. Cleavage within the transmembrane domain provides an attractive mechanism...
27.
Randow F, Youle R
Cell Host Microbe
. 2014 Apr;
15(4):403-11.
PMID: 24721569
Autophagy is an evolutionarily conserved pathway that transports cytoplasmic components for degradation into lysosomes. Selective autophagy can capture physically large objects, including cell-invading pathogens and damaged or superfluous organelles. Selectivity...
28.
Beale R, Wise H, Stuart A, Ravenhill B, Digard P, Randow F
Cell Host Microbe
. 2014 Feb;
15(2):239-47.
PMID: 24528869
Autophagy recycles cellular components and defends cells against intracellular pathogens. While viruses must evade autophagocytic destruction, some viruses can also subvert autophagy for their own benefit. The ability of influenza...
29.
Randow F, MacMicking J, James L
Science
. 2013 May;
340(6133):701-6.
PMID: 23661752
Our prevailing view of vertebrate host defense is strongly shaped by the notion of a specialized set of immune cells as sole guardians of antimicrobial resistance. Yet this view greatly...
30.
Boyle K, Randow F
Curr Opin Microbiol
. 2013 Apr;
16(3):339-48.
PMID: 23623150
Selective autophagy is an important effector mechanism of cell autonomous immunity, in particular against invasive bacterial species. Anti-bacterial autophagy is activated by rupture of bacteria-containing vacuoles and exposure of bacteria...