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Felix Frenkel

Explore the profile of Felix Frenkel including associated specialties, affiliations and a list of published articles. Areas
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Articles 10
Citations 695
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Recent Articles
1.
Ramirez C, Becker-Hapak M, Singhal K, Russler-Germain D, Frenkel F, Barnell E, et al.
Blood Adv . 2024 May; 8(15):4035-4049. PMID: 38713894
Personalized cancer vaccines designed to target neoantigens represent a promising new treatment paradigm in oncology. In contrast to classical idiotype vaccines, we hypothesized that "polyvalent" vaccines could be engineered for...
2.
Ling A, Solomon I, Landivar A, Nakashima H, Woods J, Santos A, et al.
Nature . 2023 Oct; 623(7985):157-166. PMID: 37853118
Immunotherapy failures can result from the highly suppressive tumour microenvironment that characterizes aggressive forms of cancer such as recurrent glioblastoma (rGBM). Here we report the results of a first-in-human phase...
3.
Raju Paul S, Valiev I, Korek S, Zyrin V, Shamsutdinova D, Gancharova O, et al.
FASEB Bioadv . 2023 Apr; 5(4):156-170. PMID: 37020749
Lung cancer is the leading cause of cancer-related deaths worldwide. Surgery and chemoradiation are the standard of care in early stages of non-small cell lung cancer (NSCLC), while immunotherapy is...
4.
Ghosh S, Huang J, Inkman M, Zhang J, Thotala S, Tikhonova E, et al.
Sci Transl Med . 2023 Jan; 15(680):eabn6758. PMID: 36696484
Severe and prolonged lymphopenia frequently occurs in patients with glioblastoma after standard chemoradiotherapy and has been associated with worse survival, but its underlying biological mechanism is not well understood. To...
5.
Jackson K, Antunes D, Talukder A, Maleki A, Amagai K, Salmon A, et al.
PNAS Nexus . 2022 Aug; 1(3):pgac124. PMID: 36003074
Human leukocyte antigen class I (HLA-I) molecules bind and present peptides at the cell surface to facilitate the induction of appropriate CD8+ T cell-mediated immune responses to pathogen- and self-derived...
6.
Li F, Deng L, Jackson K, Talukder A, Katailiha A, Bradley S, et al.
J Immunother Cancer . 2021 Jul; 9(7). PMID: 34244308
Background: Neoantigen (NeoAg) peptides displayed at the tumor cell surface by human leukocyte antigen molecules show exquisite tumor specificity and can elicit T cell mediated tumor rejection. However, few NeoAgs...
7.
Bagaev A, Kotlov N, Nomie K, Svekolkin V, Gafurov A, Isaeva O, et al.
Cancer Cell . 2021 May; 39(6):845-865.e7. PMID: 34019806
The clinical use of molecular targeted therapy is rapidly evolving but has primarily focused on genomic alterations. Transcriptomic analysis offers an opportunity to dissect the complexity of tumors, including the...
8.
Kotlov N, Bagaev A, Revuelta M, Phillip J, Cacciapuoti M, Antysheva Z, et al.
Cancer Discov . 2021 Feb; 11(6):1468-1489. PMID: 33541860
Diffuse large B-cell lymphoma (DLBCL) is a biologically and clinically heterogeneous disease. Transcriptomic and genetic characterization of DLBCL has increased the understanding of its intrinsic pathogenesis and provided potential therapeutic...
9.
Shah M, Enzinger P, Ko A, Ocean A, Philip P, Thakkar P, et al.
Clin Cancer Res . 2020 Jul; 26(18):4756-4766. PMID: 32641434
Purpose: We examined cabazitaxel, a novel next-generation taxoid, in patients with metastatic gastric cancer in a multicenter phase II study. Patients And Methods: Patients who have progressed on one or...
10.
Pugacheva V, Frenkel F, Korotkov E
Comput Biol Chem . 2014 May; 51:12-21. PMID: 24840641
We describe a new mathematical method for finding very diverged short tandem repeats containing a single indel. The method involves comparison of two frequency matrices: a first matrix for a...