Fabien Brossier
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Explore the profile of Fabien Brossier including associated specialties, affiliations and a list of published articles.
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18
Citations
634
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Recent Articles
1.
Walker R, Niepceron A, Ramakrishnan C, Sedano L, Hehl A, Brossier F, et al.
Parasit Vectors
. 2016 Mar;
9:124.
PMID: 26935317
Background: Eimeria is an important genus of apicomplexan parasites. A defining feature of these parasites is the oocyst, which is transmitted into the environment via the faeces of definitive hosts....
2.
Silpa L, Niepceron A, Laurent F, Brossier F, Penichon M, Enguehard-Gueiffier C, et al.
Bioorg Med Chem Lett
. 2015 Nov;
26(1):114-20.
PMID: 26597537
Screening of our chemical library to discover new molecules exhibiting in vitro activity against the invasion of host cells by Eimeria tenella revealed a lead compound with an IC50 of...
3.
Walker R, Sharman P, Miller C, Lippuner C, Okoniewski M, Eichenberger R, et al.
BMC Genomics
. 2015 Mar;
16:94.
PMID: 25765081
Background: The protozoan Eimeria tenella is a common parasite of chickens, causing avian coccidiosis, a disease of on-going concern to agricultural industries. The high prevalence of E. tenella can be...
4.
Bussiere F, Brossier F, Le Vern Y, Niepceron A, Silvestre A, de Sablet T, et al.
PLoS One
. 2015 Feb;
10(2):e0116509.
PMID: 25689363
E. tenella infection is associated with a severe intestinal disease leading to high economic losses in poultry industry. Mitogen activated protein kinases (MAPKs) are implicated in early response to infection...
5.
Moine E, Denevault-Sabourin C, Debierre-Grockiego F, Silpa L, Gorgette O, Barale J, et al.
Eur J Med Chem
. 2014 Dec;
89:386-400.
PMID: 25462254
An in vitro screening of the anti-apicomplexan activity of 51 compounds, stemming from our chemical library and from chemical synthesis, was performed. As a study model, we used Toxoplasma gondii...
6.
Gras S, Byzia A, Gilbert F, McGowan S, Drag M, Silvestre A, et al.
Eukaryot Cell
. 2014 May;
13(7):884-95.
PMID: 24839124
Aminopeptidases N are metalloproteases of the M1 family that have been reported in numerous apicomplexan parasites, including Plasmodium, Toxoplasma, Cryptosporidium, and Eimeria. While investigating the potency of aminopeptidases as therapeutic...
7.
Saidani N, Botte C, Deligny M, Bonneau A, Reader J, Lasselin R, et al.
Antimicrob Agents Chemother
. 2014 Feb;
58(5):2586-97.
PMID: 24550329
A piperidinyl-benzimidazolone scaffold has been found in the structure of different inhibitors of membrane glycerolipid metabolism, acting on enzymes manipulating diacylglycerol and phosphatidic acid. Screening a focus library of piperidinyl-benzimidazolone...
8.
Katrib M, Ikin R, Brossier F, Robinson M, Slapetova I, Sharman P, et al.
BMC Genomics
. 2012 Dec;
13:685.
PMID: 23216867
Background: Proteases regulate pathogenesis in apicomplexan parasites but investigations of proteases have been largely confined to the asexual stages of Plasmodium falciparum and Toxoplasma gondii. Thus, little is known about...
9.
Rieux A, Gras S, Lecaille F, Niepceron A, Katrib M, Smith N, et al.
PLoS One
. 2012 Mar;
7(3):e31914.
PMID: 22457711
The invasion and replication of Eimeria tenella in the chicken intestine is responsible for avian coccidiosis, a disease that has major economic impacts on poultry industries worldwide. E. tenella is...
10.
Buguliskis J, Brossier F, Shuman J, Sibley L
PLoS Pathog
. 2010 Apr;
6(4):e1000858.
PMID: 20421941
Host cell attachment by Toxoplasma gondii is dependent on polarized secretion of apical adhesins released from the micronemes. Subsequent translocation of these adhesive complexes by an actin-myosin motor powers motility...