F N Naguib
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Explore the profile of F N Naguib including associated specialties, affiliations and a list of published articles.
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35
Citations
214
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Recent Articles
11.
el Kouni M, Guarcello V, Al Safarjalani O, Naguib F
Antimicrob Agents Chemother
. 1999 Oct;
43(10):2437-43.
PMID: 10508021
The purine nucleoside analogue NBMPR (nitrobenzylthioinosine or 6-[(4-nitrobenzyl)thio]-9-beta-D-ribofuranosylpurine) was selectively phosphorylated to its nucleoside 5'-monophosphate by Toxoplasma gondii but not mammalian adenosine kinase (EC 2.7.1.20). NBMPR was also cleaved in...
12.
Guerin D, Mazeas D, Musale M, Naguib F, Al Safarjalani O, el Kouni M, et al.
Bioorg Med Chem Lett
. 1999 Jul;
9(11):1477-80.
PMID: 10386920
5-(o-Benzyloxy)benzylbarbituric acid (6) and 5-(p-benzyloxy)benzylbarbituric acid (7) were prepared and their inhibitory activities compared to 5-(m-benzyloxy)-benzylbarbituric acid (BBB) a known, potent inhibitor of uridine phosphorylase (UrdPase). Compounds 6 and 7...
13.
el Kouni M, Naguib F, Panzica R, Otter B, Chu S, Gosselin G, et al.
Biochem Pharmacol
. 1996 Jun;
51(12):1687-700.
PMID: 8687484
One hundred and fifty analogues of uridine, with various modifications to the uracil and pentose moieties, have been tested and compared with uridine with respect to their potency to bind...
14.
Ashour O, Naguib F, el Kouni M
Biochem Pharmacol
. 1996 Jun;
51(12):1601-11.
PMID: 8687475
5-(m-Benzyloxybenzyl)barbituric acid acyclonucleoside (BBBA), the most potent inhibitor known of uridine phosphorylase (UrdPase, EC 2.4.2.3), the enzyme responsible for uridine catabolism, and 2',3',5'-tri-O-acetyluridine (TAU), a prodrug of uridine, were used...
15.
Naguib F, Iltzsch M, el Kouni M, Panzica R, el Kouni M
Biochem Pharmacol
. 1995 Nov;
50(10):1685-93.
PMID: 7503772
Preliminary characterization of Toxoplasma gondii phosphoribosyltransferase activity towards purine nucleobases indicates that there are at least two enzymes present in these parasites. One enzyme uses hypoxanthine, guanine, and xanthine as...
16.
Ashour O, Naguib F, Khalifa M, Abdel-Raheem M, Panzica R, el Kouni M
Cancer Res
. 1995 Mar;
55(5):1092-8.
PMID: 7866994
5-(Benzyloxybenzyl)barbituric acid acyclonucleoside (BBBA) was recently synthesized as a potent and specific inhibitor of uridine phosphorylase (EC 2.4.2.3), the enzyme responsible for the catabolism of 5-fluoro-2'-deoxyuridine (FdUrd) in many types...
17.
Naguib F, Hao S, el Kouni M
Cancer Res
. 1994 Oct;
54(19):5166-70.
PMID: 7923135
5-Benzyloxybenzyluracil (BBU) is the most potent inhibitor (Ki approximately 30 nM) of dihydrouracil dehydrogenase (EC 1.3.1.2), the first enzyme in the catabolic pathway of pyrimidine bases and their analogues, including...
18.
Goudgaon N, Naguib F, el Kouni M, Schinazi R
J Med Chem
. 1993 Dec;
36(26):4250-4.
PMID: 8277507
Lithiation of 5-bromo-2,4-bis(benzyloxy)pyrimidine (3) with n-BuLi at -80 degrees C followed by the addition of diphenyl diselenide or diphenyl disulfide as an electrophile furnished the corresponding 5-(phenylhetera)-2,4-bis(benzyloxy)pyrimidine, which on exposure...
19.
Naguib F, Levesque D, Wang E, Panzica R, el Kouni M
Biochem Pharmacol
. 1993 Oct;
46(7):1273-83.
PMID: 8216379
5-Benzylbarbituric acid derivatives were synthesized as a series of new, specific, and potent inhibitors of uridine phosphorylase. Among these, 5-(m-benzyloxy)benzyl-1-[(2-hydroxyethoxy)methyl] barbituric acid (5-benzyloxybenzylbarbituric acid acyclonucleoside, BBBA) was found to be...
20.
el Kouni M, el Kouni M, Naguib F
Cancer Res
. 1993 Aug;
53(16):3687-93.
PMID: 8339277
Enzyme inhibition studies on extracts from human liver, mouse liver, and human placenta indicate that there are considerable differences between human and murine hepatic uridine phosphorylases (UrdPase, EC 2.4.2.3) and...