Evripidis Gavathiotis
Overview
Explore the profile of Evripidis Gavathiotis including associated specialties, affiliations and a list of published articles.
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86
Citations
9718
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Recent Articles
1.
Clayton J, Romany A, Matenoglou E, Gavathiotis E, Poulikakos P, Shen J
Elife
. 2025 Feb;
13.
PMID: 39945510
Aberrant signaling of BRAF is a major cancer driver. Current FDA-approved RAF inhibitors selectively inhibit the monomeric BRAF and suffer from tumor resistance. Recently, dimer-selective and equipotent RAF inhibitors have...
2.
Asciolla J, Wu X, Adamopoulos C, Gavathiotis E, Poulikakos P
Nat Cancer
. 2025 Jan;
6(1):24-40.
PMID: 39885369
Cyclin-dependent kinases (CDKs) 4 and 6 (CDK4/6) are important regulators of the cell cycle. Selective CDK4/6 small-molecule inhibitors have shown clinical activity in hormonal receptor-positive (HR) metastatic breast cancer, but...
3.
Rahman F, Johnson J, Kbaich M, Meneses-Salas E, Shukla A, Chen D, et al.
Mol Cell Biol
. 2024 Oct;
44(12):577-589.
PMID: 39434668
Rab11 family interacting protein 4 (Rab11-FIP4) regulates endocytic trafficking. A possible role for Rab11-FIP4 in the regulation of lysosomal function has been proposed, but its precise function in the regulation...
4.
Li D, Lopez A, Shrivastava N, Chan W, Thomas C, Burk R, et al.
Oral Oncol
. 2024 Oct;
159:107069.
PMID: 39423550
Evasion of apoptosis promotes tumor survival and contributes to resistance to cancer therapeutics in head and neck squamous cell carcinoma (HNSCC). Our recent work has demonstrated that HNSCC's highly express...
5.
Identification of functional rare coding variants in IGF-1 gene in humans with exceptional longevity
Ali A, Zhang Z, Gao T, Aleksic S, Gavathiotis E, Barzilai N, et al.
bioRxiv
. 2024 Oct;
PMID: 39416202
Diminished signaling via insulin/insulin-like growth factor-1 (IGF-1) axis is associated with longevity in different model organisms. IGF-1 gene is highly conserved across species, with only few evolutionary changes identified in...
6.
Carling G, Fan L, Foxe N, Norman K, Wong M, Zhu D, et al.
Neuron
. 2024 Oct;
112(23):3877-3896.e8.
PMID: 39353433
The strongest risk factors for late-onset sporadic Alzheimer's disease (AD) include the ε4 allele of apolipoprotein E (APOE), the R47H variant of triggering receptor expressed on myeloid cells 2 (TREM2),...
7.
Reynolds C, Pelka S, Gjergjova F, Tasset I, Khawaja R, Lindenau K, et al.
Proc Natl Acad Sci U S A
. 2024 Sep;
121(38):e2322929121.
PMID: 39259591
Chaperone-mediated autophagy (CMA) is a selective form of autophagy that contributes to the maintenance of cellular homeostasis. CMA activity declines with age in most tissues and systems, including the immune...
8.
Chakraborty S, Morganti C, Pena B, Zhang H, Verma D, Zaldana K, et al.
bioRxiv
. 2024 Aug;
PMID: 39211137
Statement Of Purpose: Five-year survival from AML is dismal at 30%. Our prior research demonstrated STAT3 over-expression in AML HSPC's to be associated with inferior survival. We now explore STAT3...
9.
Lopez-Polo V, Maus M, Zacharioudakis E, Lafarga M, Stephan-Otto Attolini C, Marques F, et al.
Nat Commun
. 2024 Aug;
15(1):7378.
PMID: 39191740
The escape of mitochondrial double-stranded dsRNA (mt-dsRNA) into the cytosol has been recently linked to a number of inflammatory diseases. Here, we report that the release of mt-dsRNA into the...
10.
Carling G, Fan L, Foxe N, Norman K, Ye P, Wong M, et al.
bioRxiv
. 2024 Feb;
PMID: 38328219
The strongest risk factors for Alzheimer's disease (AD) include the χ4 allele of apolipoprotein E (APOE), the variant of triggering receptor expressed on myeloid cells 2 (TREM2), and female sex....