Eunyong Park
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Explore the profile of Eunyong Park including associated specialties, affiliations and a list of published articles.
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28
Citations
1251
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Recent Articles
1.
Wu K, Itskanov S, Lynch D, Chen Y, Turner A, Gumbart J, et al.
Nat Commun
. 2024 Mar;
15(1):2182.
PMID: 38467638
Doa10 (MARCHF6 in metazoans) is a large polytopic membrane-embedded E3 ubiquitin ligase in the endoplasmic reticulum (ER) that plays an important role in quality control of cytosolic and ER proteins....
2.
Wu K, Itskanov S, Lynch D, Chen Y, Turner A, Gumbart J, et al.
bioRxiv
. 2024 Jan;
PMID: 38260251
Doa10 (MARCH6 in metazoans) is a large polytopic membrane-embedded E3 ubiquitin ligase in the endoplasmic reticulum (ER) that plays an important role in quality control of cytosolic and ER proteins....
3.
Sim S, Chen Y, Lynch D, Gumbart J, Park E
Nature
. 2023 Jun;
621(7979):620-626.
PMID: 37344598
Mitochondria import nearly all of their approximately 1,000-2,000 constituent proteins from the cytosol across their double-membrane envelope. Genetic and biochemical studies have shown that the conserved protein translocase, termed the...
4.
Itskanov S, Wang L, Junne T, Sherriff R, Xiao L, Blanchard N, et al.
Nat Chem Biol
. 2023 May;
19(9):1063-1071.
PMID: 37169959
The Sec61 complex forms a protein-conducting channel in the endoplasmic reticulum membrane that is required for secretion of soluble proteins and production of many membrane proteins. Several natural and synthetic...
5.
Sim S, Park E
Curr Opin Struct Biol
. 2023 Feb;
79:102531.
PMID: 36724561
P5A- and P5B- ATPases, or collectively P5-ATPases, are eukaryotic-specific ATP-dependent transporters that are important for the function of the endoplasmic reticulum (ER) and endo-/lysosomes. However, their substrate specificities had remained...
6.
Shin H, Citron Y, Wang L, Tribouillard L, Goul C, Stipp R, et al.
Science
. 2022 Aug;
377(6612):1290-1298.
PMID: 36007018
Lysosomes coordinate cellular metabolism and growth upon sensing of essential nutrients, including cholesterol. Through bioinformatic analysis of lysosomal proteomes, we identified lysosomal cholesterol signaling (LYCHOS, previously annotated as G protein-coupled...
7.
Itskanov S, Park E
Cold Spring Harb Perspect Biol
. 2022 Aug;
15(1).
PMID: 35940906
The endoplasmic reticulum (ER) is a major site for protein synthesis, folding, and maturation in eukaryotic cells, responsible for production of secretory proteins and most integral membrane proteins. The universally...
8.
Sim S, von Bulow S, Hummer G, Park E
Mol Cell
. 2021 Oct;
81(22):4635-4649.e8.
PMID: 34715013
Polyamines are small, organic polycations that are ubiquitous and essential to all forms of life. Currently, how polyamines are transported across membranes is not understood. Recent studies have suggested that...
9.
Itskanov S, Kuo K, Gumbart J, Park E
Nat Struct Mol Biol
. 2021 Jan;
28(2):162-172.
PMID: 33398175
Many proteins are transported into the endoplasmic reticulum by the universally conserved Sec61 channel. Post-translational transport requires two additional proteins, Sec62 and Sec63, but their functions are poorly defined. In...
10.
McKenna M, Sim S, Ordureau A, Wei L, Harper J, Shao S, et al.
Science
. 2020 Sep;
369(6511).
PMID: 32973005
Organelle identity depends on protein composition. How mistargeted proteins are selectively recognized and removed from organelles is incompletely understood. Here, we found that the orphan P5A-adenosine triphosphatase (ATPase) transporter ATP13A1...