Tom A Rapoport
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Explore the profile of Tom A Rapoport including associated specialties, affiliations and a list of published articles.
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128
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11211
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Recent Articles
1.
Zhao D, Wu X, Rapoport T
Nat Struct Mol Biol
. 2025 Feb;
PMID: 39930008
Misfolded glycoproteins in the endoplasmic reticulum (ER) lumen are translocated into the cytosol and degraded by the proteasome, a conserved process called ER-associated protein degradation (ERAD). In Saccharomyces cerevisiae, the...
2.
Zhao D, Wu X, Rapoport T
bioRxiv
. 2024 Oct;
PMID: 39464000
Misfolded glycoproteins in the endoplasmic reticulum (ER) lumen are translocated into the cytosol and degraded by the proteasome, a conserved process called ER-associated protein degradation (ERAD). In , the glycan...
3.
Shibata Y, Mazur E, Pan B, Paulo J, Gygi S, Chavan S, et al.
Nat Commun
. 2024 Oct;
15(1):8655.
PMID: 39368994
The endoplasmic reticulum (ER) is shaped by abundant membrane curvature-generating proteins that include the REEP family member REEP5. The REEP1 subfamily, consisting of four proteins in mammals (REEP1-4), is less...
4.
Li H, Ji Z, Paulo J, Gygi S, Rapoport T
Mol Cell
. 2024 Feb;
84(7):1290-1303.e7.
PMID: 38401542
Most eukaryotic proteins are degraded by the 26S proteasome after modification with a polyubiquitin chain. Substrates lacking unstructured segments cannot be degraded directly and require prior unfolding by the Cdc48...
5.
Rapoport T
Interface Focus
. 2024 Feb;
14(1):20230024.
PMID: 38344406
Metabolic control theory (MCA) is celebrating its 50th anniversary. The theory introduced quantitative terms that describe the importance of an enzyme for the regulation of the overall flux and of...
6.
Li H, Ji Z, Paulo J, Gygi S, Rapoport T
bioRxiv
. 2024 Jan;
PMID: 38187576
Most eukaryotic proteins are degraded by the 26S proteasome after modification with a polyubiquitin chain. Substrates lacking unstructured segments cannot be degraded directly and require prior unfolding by the Cdc48...
7.
Rapoport T
Annu Rev Biochem
. 2023 Nov;
93(1):1-20.
PMID: 38029368
Writing a career retrospective for this prestigious series is a huge challenge. Is my story really of that much interest? One thing that is different about my life in science...
8.
Skowyra M, Feng P, Rapoport T
Trends Cell Biol
. 2023 Sep;
34(5):388-405.
PMID: 37743160
Peroxisomes are vital metabolic organelles that import their lumenal (matrix) enzymes from the cytosol using mobile receptors. Surprisingly, the receptors can even import folded proteins, but the underlying mechanism has...
9.
Wang N, Shibata Y, Paulo J, Gygi S, Rapoport T
Nat Commun
. 2023 Aug;
14(1):4765.
PMID: 37553386
Organelles are shaped by curvature-generating proteins, which include the reticulons and REEPs that are involved in forming the endoplasmic reticulum (ER). A conserved REEP subfamily differs from the ER-shaping REEPs...
10.
Skowyra M, Rapoport T
STAR Protoc
. 2023 Feb;
4(1):102111.
PMID: 36853666
Peroxisomes are vital metabolic organelles whose matrix enzymes are imported from the cytosol in a folded state by the soluble receptor PEX5. The import mechanism has been challenging to decipher...