Eugene Melamud
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Explore the profile of Eugene Melamud including associated specialties, affiliations and a list of published articles.
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28
Citations
2092
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Recent Articles
1.
Wang Q, Huang J, Chan L, Haste N, Olsson N, Gaun A, et al.
bioRxiv
. 2025 Feb;
PMID: 39975113
Mutations in apolipoprotein L1 (APOL1) are strongly associated with an increased risk of kidney disease in individuals of African ancestry, yet the underlying mechanisms remain largely unknown. Plasma proteomics provides...
2.
Sun B, Chiou J, Traylor M, Benner C, Hsu Y, Richardson T, et al.
Nature
. 2023 Oct;
622(7982):329-338.
PMID: 37794186
The Pharma Proteomics Project is a precompetitive biopharmaceutical consortium characterizing the plasma proteomic profiles of 54,219 UK Biobank participants. Here we provide a detailed summary of this initiative, including technical...
3.
Sethi A, Ruby J, Veras M, Telis N, Melamud E
Nat Commun
. 2023 May;
14(1):2644.
PMID: 37156767
Diffuse idiopathic skeletal hyperostosis (DISH) is a condition where adjacent vertebrae become fused through formation of osteophytes. The genetic and epidemiological etiology of this condition is not well understood. Here,...
4.
Sethi A, Melamud E
Cell Rep Methods
. 2023 Jan;
2(12):100356.
PMID: 36590696
We describe methodology for joint reconstruction of physiological-survival networks from observational data capable of identifying key survival-associated variables, inferring a minimal physiological network structure, and bridging this network to the...
5.
Murad N, Melamud E
Sci Rep
. 2022 Dec;
12(1):21893.
PMID: 36535980
There is a multitude of pathological conditions that affect human health, yet we currently lack a predictive model for most diseases, and underlying mechanisms that are shared by multiple diseases...
6.
Sethi A, Taylor D, Ruby J, Venkataraman J, Sorokin E, Cule M, et al.
Front Cardiovasc Med
. 2022 Oct;
9:1003246.
PMID: 36277789
Calcification of large arteries is a high-risk factor in the development of cardiovascular diseases, however, due to the lack of routine monitoring, the pathology remains severely under-diagnosed and prevalence in...
7.
Seitzer P, Bennett B, Melamud E
Metabolites
. 2022 Jul;
12(8).
PMID: 35893250
MAVEN, an open-source software program for analysis of LC-MS metabolomics data, was originally released in 2010. As mass spectrometry has advanced in the intervening years, MAVEN has been periodically updated...
8.
Melamud E, Taylor D, Sethi A, Cule M, Baryshnikova A, Saleheen D, et al.
J Clin Invest
. 2020 Jan;
130(2):575-581.
PMID: 31929188
Technological advances in rapid data acquisition have transformed medical biology into a data mining field, where new data sets are routinely dissected and analyzed by statistical models of ever-increasing complexity....
9.
Lewis K, Soifer I, Melamud E, Roy M, McIsaac R, Hibbs M, et al.
Mamm Genome
. 2016 Jul;
27(7-8):259-78.
PMID: 27364349
Animals have evolved to survive, and even thrive, in different environments. Genetic adaptations may have indirectly created phenotypes that also resulted in a longer lifespan. One example of this phenomenon...
10.
Shor B, Kahler J, Dougher M, Xu J, Mack M, Rosfjord E, et al.
Clin Cancer Res
. 2015 Aug;
22(2):383-94.
PMID: 26319086
Purpose: Targeted treatment of solid or liquid tumors with antibody-drug conjugates (ADCs) can lead to promising clinical benefit. The aim of the study is to investigate combination regimens of auristatin-based...