Ethan Dmitrovsky
Overview
Explore the profile of Ethan Dmitrovsky including associated specialties, affiliations and a list of published articles.
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91
Citations
3238
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Recent Articles
11.
Zheng L, Chen Z, Kawakami M, Chen Y, Roszik J, Mustachio L, et al.
Mol Cancer Ther
. 2019 Jul;
18(10):1775-1786.
PMID: 31358662
The spindle assembly checkpoint maintains genomic integrity. A key component is tyrosine threonine kinase (TTK, also known as Mps1). TTK antagonism is hypothesized to cause genomic instability and cell death....
12.
Kawakami M, Mustachio L, Zheng L, Chen Y, Rodriguez-Canales J, Mino B, et al.
Proc Natl Acad Sci U S A
. 2018 Nov;
115(46):E10810-E10811.
PMID: 30377273
No abstract available.
13.
Kawakami M, Liu X, Dmitrovsky E
Annu Rev Pharmacol Toxicol
. 2018 Aug;
59:361-377.
PMID: 30110577
Aneuploidy is a hallmark of cancer. Defects in chromosome segregation result in aneuploidy. Multiple pathways are engaged in this process, including errors in kinetochore-microtubule attachments, supernumerary centrosomes, spindle assembly checkpoint...
14.
Chen L, Diao L, Yang Y, Yi X, Rodriguez B, Li Y, et al.
Cancer Discov
. 2018 Jul;
8(9):1156-1175.
PMID: 30012853
Although treatment with immune checkpoint inhibitors provides promising benefit for patients with cancer, optimal use is encumbered by high resistance rates and requires a thorough understanding of resistance mechanisms. We...
15.
Kawakami M, Mustachio L, Liu X, Dmitrovsky E
Mol Cancer Ther
. 2018 Mar;
17(4):724-731.
PMID: 29559545
Cancer cells often have supernumerary centrosomes that promote genomic instability, a pathognomonic feature of cancer. During mitosis, cancer cells with supernumerary centrosomes undergo bipolar cell division by clustering centrosomes into...
16.
Kawakami M, Mustachio L, Zheng L, Chen Y, Rodriguez-Canales J, Mino B, et al.
Proc Natl Acad Sci U S A
. 2018 Feb;
115(8):1913-1918.
PMID: 29434041
Polo-like kinase 4 (PLK4) is a serine/threonine kinase regulating centriole duplication. CFI-400945 is a highly selective PLK4 inhibitor that deregulates centriole duplication, causing mitotic defects and death of aneuploid cancers....
17.
Mustachio L, Lu Y, Kawakami M, Roszik J, Freemantle S, Liu X, et al.
Cancer Res
. 2018 Jan;
78(3):587-592.
PMID: 29343520
Ubiquitination and ubiquitin-like posttranslational modifications (PTM) regulate activity and stability of oncoproteins and tumor suppressors. This implicates PTMs as antineoplastic targets. One way to alter PTMs is to inhibit activity...
18.
Yim C, Bikorimana E, Khan E, Warzecha J, Shin L, Rodriguez J, et al.
Cell Cycle
. 2017 Sep;
16(21):2146-2155.
PMID: 28910567
G0/G1 switch gene 2 (G0S2) is a direct retinoic acid target implicated in cancer biology and therapy based on frequent methylation-mediated silencing in diverse solid tumors. We recently reported that...
19.
Sepesi B, Correa A, Dmitrovsky E, Liu X
J Thorac Oncol
. 2017 Aug;
12(9):e150-e151.
PMID: 28838719
No abstract available.
20.
Sepesi B, Gold K, Correa A, Heymach J, Vaporciyan A, Roszik J, et al.
J Thorac Oncol
. 2017 May;
12(8):1280-1287.
PMID: 28552766
Background: Population studies suggest that high body mass index (BMI) correlates with a reduced risk for death from lung cancer. The aim of our study was to evaluate definitively the...